Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia

Endotoxemia and the systemic inflammatory response syndrome have a significant impact on post-surgery outcome, particularly in the elderly. The cytokine response to endotoxin is altered by aging. We tested the hypothesis that vulnerability to endotoxemic cardiac depression increases with aging due t...

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Veröffentlicht in:	Critical care (London, England) England), 2014-09, Vol.18 (5), p.527-527, Article 527
Hauptverfasser:	Slimani, Hanan, Zhai, Yufeng, Yousif, Nasser G, Ao, Lihua, Zeng, Qingchun, Fullerton, David A, Meng, Xianzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Analysis Animals Biomarkers - blood Chemokine CCL2 - antagonists & inhibitors Chemokine CCL2 - biosynthesis Chemokine CCL2 - blood Chemokine CCL2 - immunology Cytokines - blood Endotoxemia - metabolism Enzyme-Linked Immunosorbent Assay - methods Interleukins Mice Mice, Inbred C57BL Myocardium - metabolism Ventricular Dysfunction, Left
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