Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs

Allogeneic hematopoietic stem cell (HSC) transplantation (HSCT) is currently the leading strategy to manage acute myeloid leukemia (AML). However, treatment-related morbidity limits the patient generalizability of HSCT use, and the survival of leukemic stem cells (LSCs) within protective areas of th...

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Veröffentlicht in:	The Journal of experimental medicine 2014-09, Vol.211 (10), p.1925-1935
Hauptverfasser:	Boyd, Allison L, Campbell, Clinton J V, Hopkins, Claudia I, Fiebig-Comyn, Aline, Russell, Jennifer, Ulemek, Jelena, Foley, Ronan, Leber, Brian, Xenocostas, Anargyros, Collins, Tony J, Bhatia, Mickie
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Bone Marrow - physiology Brief Definitive Report Hematopoietic Stem Cell Transplantation - methods Humans Leukemia, Myeloid, Acute - physiopathology Leukemia, Myeloid, Acute - therapy Microscopy, Fluorescence Neoplastic Stem Cells - metabolism Stem Cell Niche - physiology Transplantation, Homologous Tumor Microenvironment - physiology
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