Increased DNA methyltransferase 3b (Dnmt3b)-mediated CpG island methylation stimulated by oxidative stress inhibits expression of a gene required for neural tube and neural crest development in diabetic pregnancy

Previous studies have shown that diabetic embryopathy results from impaired expression of genes that are required for formation of embryonic structures. We have focused on Pax3, a gene that is expressed in embryonic neuroepithelium and is required for neural tube closure. Pax3 expression is inhibite...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2014-10, Vol.63 (10), p.3512-3522
Hauptverfasser:	Wei, Dan, Loeken, Mary R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Complications CpG Islands - physiology Deoxyribonucleic acid Diabetes DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA Methyltransferase 3B Female Gene Expression Hyperglycemia - genetics Hyperglycemia - metabolism Mice Mice, Inbred ICR Neural Crest - embryology Neural Crest - metabolism Neural Tube - embryology Neural Tube - metabolism Oxidative stress Oxidative Stress - physiology Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism PAX3 Transcription Factor Pregnancy Ribonucleic acid RNA
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