Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

Mislocalization of proteins is a common feature of cancer cells. Since localization of proteins is tightly linked to its function, cancer cells can inactivate function of a tumor suppressor protein through mislocalization. The nuclear exportin CRM1/XPO 1 is upregulated in many cancers. Targeting XPO...

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Veröffentlicht in:	Oncotarget 2014-08, Vol.5 (15), p.6102-6112
Hauptverfasser:	Mendonca, Janet, Sharma, Anup, Kim, Hae-Soo, Hammers, Hans, Meeker, Alan, De Marzo, Angelo, Carducci, Michael, Kauffman, Michael, Shacham, Sharon, Kachhap, Sushant
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Antineoplastic Agents - pharmacology Cell Line, Tumor Humans Male Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Research Paper Transfection
Online-Zugang:	Volltext
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