A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this act...

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Veröffentlicht in:	Fitoterapia 2014-10, Vol.98, p.11-21
Hauptverfasser:	Lutz, Joseph A., Kulshrestha, Manish, Rogers, Dennis T., Littleton, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Anti-Inflammatory Agents - pharmacology Cell Line Drug discovery Flavonoids Flavonoids - pharmacology Hippocampus - drug effects Male Mice Microglia - drug effects Molecular Structure Neuroinflammation Nicotinic acetylcholine receptors Nicotinic Antagonists - pharmacology Plant Components, Aerial - chemistry Quercetin - analogs & derivatives Quercetin - pharmacology Rats, Sprague-Dawley Solidago - chemistry Solidago nemoralis
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