Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis

Though tumor necrosis factor related apoptosis inducing ligand (TRAIL) has been used as a potent anticancer agent, TRAIL resistance is a hot-issue in cancer therapy. We investigated the antitumor mechanism of Tanshinone I to sensitize prostate cancer cells to TRAIL. Comibination of Tanshinone I and...

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Veröffentlicht in:	Oncotarget 2014-07, Vol.5 (14), p.5624-5636
Hauptverfasser:	Shin, Eun Ah, Sohn, Eun Jung, Won, Gunho, Choi, Jeong-Un, Jeong, Myongsuk, Kim, Bonglee, Kim, Min-Jeong, Kim, Sung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Cell Line, Tumor Diterpenes, Abietane - administration & dosage Diterpenes, Abietane - pharmacology Drug Synergism Humans Male MicroRNAs - biosynthesis MicroRNAs - genetics Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Reactive Oxygen Species - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Research Paper TNF-Related Apoptosis-Inducing Ligand - administration & dosage TNF-Related Apoptosis-Inducing Ligand - pharmacology Transfection Up-Regulation
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