Autoradiographic evaluation of [3H]CUMI-101, a novel, selective 5-HT1AR ligand in human and baboon brain

[11C]CUMI-101 is the first selective serotonin receptor (5-HT1AR) partial agonist radiotracer for positron emission tomography (PET) tested in vivo in nonhuman primates and humans. We evaluated specific binding of [3H]CUMI-101 by quantitative autoradiography studies in postmortem baboon and human br...

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Veröffentlicht in:	Brain research 2013-04, Vol.1507, p.11-18
Hauptverfasser:	Kumar, J.S. Dileep, Parsey, Ramin V., Kassir, Suham A., Majo, Vattoly J., Milak, Matthew S., Prabhakaran, Jaya, Simpson, Norman R., Underwood, Mark D., Mann, J. John, Arango, Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT1AR agonists Animals antagonists Autoradiography Biological and medical sciences Brain Brain - anatomy & histology Brain - diagnostic imaging Brain - metabolism Cell receptors Cell structures and functions Drug Partial Agonism Fundamental and applied biological sciences. Psychology Humans in vitro studies Ligands Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Papio Piperazines - metabolism Positron-Emission Tomography Primates Receptor, Serotonin, 5-HT1A - metabolism receptors serotonin Serotonin 5-HT1 Receptor Agonists - metabolism Serotonin Agonist Triazines - metabolism Tritium
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