Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neuropathy

•We compare the effects of four microtubule-targeting drugs on fast axonal transport.•All four drugs inhibit anterograde transport in axoplasm, with varying potencies.•Vincristine and ixabepilone also inhibit retrograde transport in axoplasm.•Vincristine and ixabepilone slow the gliding of kinesin-1...

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