Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Hauptverfasser:	Matulis, Daumantas, Ivanova, Jekaterina, Kairys, Visvaldas, Zubrienė, Asta, Baranauskienė, Lina, Morkūnaitė, Vaida, Trapencieris, Pēteris
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - metabolism Control Enzymes Experiments Fluorescence Health aspects Humans Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Ligands Methods Molecular Docking Simulation Physiological aspects Proteins Recombinant Proteins - metabolism Saccharin - chemistry Saccharin - pharmacology Studies Sulfonamides Sulfonamides - chemistry Sulfonamides - pharmacology Temperature Thermodynamics
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