Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors

The clinical efficacy of chimeric antigen receptor (CAR)-redirected T cells remains marginal in solid tumors compared with leukemias. Failures have been attributed to insufficient T-cell migration and to the highly immunosuppressive milieu of solid tumors. To overcome these obstacles, we have combin...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-09, Vol.74 (18), p.5195-5205
Hauptverfasser:	Nishio, Nobuhiro, Diaconu, Iulia, Liu, Hao, Cerullo, Vincenzo, Caruana, Ignazio, Hoyos, Valentina, Bouchier-Hayes, Lisa, Savoldo, Barbara, Dotti, Gianpietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cytokines - immunology Disease Models, Animal Immunotherapy - methods Mice Mice, Inbred NOD Microscopy, Confocal Neuroblastoma - immunology Neuroblastoma - therapy Neuroblastoma - virology Oncolytic Virotherapy - methods Oncolytic Viruses - immunology Receptors, Antigen, T-Cell - immunology T-Lymphocytes - immunology Xenograft Model Antitumor Assays
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