Depolarization of Cardiac Membrane Potential Synchronizes Calcium Sparks and Waves in Tissue

The diastolic membrane potential (Vm) can be hyperpolarized or depolarized by various factors such as hyperkalemia or hypokalemia in the long term, or by delayed afterdepolarizations in the short term. In this study, we investigate how Vm affects Ca sparks and waves. We use a physiologically detaile...

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Veröffentlicht in:	Biophysical journal 2014-09, Vol.107 (6), p.1313-1317
Hauptverfasser:	Sato, Daisuke, Bartos, Daniel C., Ginsburg, Kenneth S., Bers, Donald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Calcium Signaling Cardiovascular system Channels and Transporters Mathematical models Membrane Potentials Membranes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Propagation Rats Rats, Sprague-Dawley Sodium Sodium-Calcium Exchanger - metabolism Tissues
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