Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats

The lipid peroxidation end-product 4-hydroxynonenal (4-HNE) is generated in tissues during oxidative stress. As a reactive aldehyde, it forms Michael adducts with nucleophiles, a process that disrupts cellular functioning. Liver, lung and brain are highly sensitive to xenobiotic-induced oxidative st...

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Veröffentlicht in:	Toxicology and applied pharmacology 2014-08, Vol.279 (1), p.43-52
Hauptverfasser:	Zheng, Ruijin, Dragomir, Ana-Cristina, Mishin, Vladimir, Richardson, Jason R., Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal 60 APPLIED LIFE SCIENCES ALCOHOL DEHYDROGENASE Aldehydes - antagonists & inhibitors Aldehydes - metabolism ANIMAL TISSUES Animals Antibodies, Blocking - pharmacology Biological and medical sciences Blotting, Western BRAIN Brain - drug effects Brain - enzymology Brain - metabolism Enzyme Inhibitors - pharmacology GLUTATHIONE Glutathione Transferase - antagonists & inhibitors Glutathione Transferase - metabolism Hepatocytes - drug effects Hepatocytes - metabolism HOMOGENATES INJURIES Kinetics Lipid peroxidation LIPIDS LIVER Liver - drug effects Liver - enzymology Liver - metabolism LIVER CELLS Lung - drug effects Lung - enzymology Lung - metabolism LUNGS Male Medical sciences METABOLISM MICE Mice, Inbred C57BL NAD Neurotoxicity OXIDATION Pulmonary toxicity RATS Rats, Long-Evans Reactive oxygen species Species Specificity STRESSES Subcellular Fractions - enzymology Subcellular Fractions - metabolism TOXICITY Toxicology TRANSFERASES
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