Identification of a recurrent transforming UBR5-ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer which is prevalent in southern China, south‐east Asia and northern Africa. The development and stepwise progression of NPC involves accumulation of multiple gross genetic changes during the clonal expansion of Epstein–Barr vir...

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Veröffentlicht in:	The Journal of pathology 2013-10, Vol.231 (2), p.158-167
Hauptverfasser:	Chung, Grace TY, Lung, Raymond WM, Hui, Angela BY, Yip, Kevin YL, Woo, John KS, Chow, Chit, Tong, Carol YK, Lee, Sau-Dan, Yuen, Jessie WF, Lun, Samantha WM, Tso, Ken KY, Wong, Nathalie, Tsao, Sai-Wah, Yip, Timothy TC, Busson, Pierre, Kim, Hyungtae, Seo, Jeong-Sun, O'Sullivan, Brian, Liu, Fei-Fei, To, Ka-Fai, Lo, Kwok-Wai
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Amino Acid Sequence Animals Blotting, Western Carcinoma Cell Line, Tumor DNA-Binding Proteins - genetics Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - genetics Female gene rearrangement Humans In Situ Hybridization, Fluorescence Male Mice Mice, Nude Middle Aged Molecular Sequence Data Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - virology oncogene Oncogenes - genetics Original Papers Real-Time Polymerase Chain Reaction Recombinant Fusion Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Transcriptome transcriptome sequencing Transfection Transplantation, Heterologous Ubiquitin-Protein Ligases - genetics UBR5-ZNF423 fusion
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