Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR

Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1...

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Veröffentlicht in:	Molecular carcinogenesis 2005-11, Vol.44 (3), p.174-182
Hauptverfasser:	Thavathiru, Elangovan, Ludes-Meyers, John H., MacLeod, Michael C., Aldaz, C. Marcelo
Format:	Artikel
Sprache:	eng
Schlagworte:	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - pharmacology Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - metabolism BPDE Carcinogens, Environmental - pharmacology Cell Line, Tumor Chromosome Fragile Sites - genetics DNA damage Down-Regulation - drug effects Down-Regulation - radiation effects FHIT fragile sites Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - radiation effects Humans Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oxidoreductases - genetics Oxidoreductases - metabolism Radiation, Ionizing Tumor Suppressor Protein p53 - genetics Tumor Suppressor Proteins Ultraviolet Rays WW Domain-Containing Oxidoreductase WWOX
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