The Microbial Opsin Family of Optogenetic Tools
The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular...
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| Veröffentlicht in: | Cell 2011-12, Vol.147 (7), p.1446-1457 |
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| creator | Zhang, Feng Vierock, Johannes Yizhar, Ofer Fenno, Lief E. Tsunoda, Satoshi Kianianmomeni, Arash Prigge, Matthias Berndt, Andre Cushman, John Polle, Jürgen Magnuson, Jon Hegemann, Peter Deisseroth, Karl |
| description | The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines. |
| doi_str_mv | 10.1016/j.cell.2011.12.004 |
| format | Article |
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(PNNL), Richland, WA (United States)</creatorcontrib><title>The Microbial Opsin Family of Optogenetic Tools</title><title>Cell</title><addtitle>Cell</addtitle><description>The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | 60 APPLIED LIFE SCIENCES algae Amino Acid Sequence Animals Bacterial Proteins - chemistry Bacterial Proteins - genetics BASIC BIOLOGICAL SCIENCES CONVERGENCE engineering Fungal Proteins - chemistry Fungal Proteins - genetics genome genomics Humans ion channels Joint Genome Institute light sensing Models, Molecular Molecular Sequence Data opsin Opsins - chemistry Opsins - genetics Opsins - metabolism optogenetics phototroph Phylogeny PROCESSING protein Protein Engineering sequence utilization VELOCITY |
| title | The Microbial Opsin Family of Optogenetic Tools |
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