Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary Hepatocellular Carcinoma (HCC) in a Chinese population
Objectives Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR an...
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| Veröffentlicht in: | Cancer causes & control 2007-08, Vol.18 (6), p.665-675 |
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| creator | Mu, Li-Na Cao, Wei Zhang, Zuo-Feng Cai, Lin Jiang, Qing-Wu You, Nai-Chieh Goldstein, Binh Yang Wei, Guo-Rong Chen, Chuan-Wei Lu, Qing-Yi Zhou, Xue-Fu Ding, Bao-Guo Chang, Jun Yu, Shun-Zhang |
| description | Objectives Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors. Methods A population-based case-control study was conducted in Taixing, China. MTHFR C677T and A1298C were assayed by PCR-RFLP techniques. Results The frequency of MTHFR 677 C/C wild homozygotes genotype was 25.8% in cases, which was lower than that in controls (34.5%). The adjusted odds ratios (ORs) for the MTHFR 677 C/T and T/T genotype were 1.66(95% CI: 1.06-2.61), 1.21(95% CI: 0.65-2.28) respectively when compared with the MTHFR 677 C/C genotype. Subjects carrying any T genotype have the increased risk of 1.55(95% CI: 1.01-2.40) for development of primary hepatocellular carcinoma. A high degree of linkage disequilibrium was observed between the C677T and A1298C polymorphisms, with the D' of 0.887 and p < 0.01. The MTHFR 677 any T genotype was suggested to have potentially more than multiplicative interactions with raw water drinking with p-value for adjusted interaction of 0.03. Conclusion We observed that the MTHFR 677 C/T genotype was associated with an increased risk of primary liver cancer in a Chinese population. The polymorphism of MTHFR 677 might modify the effects of raw water drinking on the risk of primary hepatocellular carcinoma. |
| doi_str_mv | 10.1007/s10552-007-9012-x |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4165489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>29736669</jstor_id><sourcerecordid>29736669</sourcerecordid><originalsourceid>FETCH-LOGICAL-c595t-bc17a07da72bc3c6d739521c8110a9449ba73461ec792cf41df8cd8cc6d4c29d3</originalsourceid><addsrcrecordid>eNqFkt-K1DAUxoso7rj6AF6oQUF2L6onSZM0N8JSXEfYRdDZ65BJ023Htukmrew8im9raof1D4hXCZzf-XLOly9JnmJ4gwHE24CBMZLGayoBk_T2XrLCTNBUEMLuJyuQTKSMZPQoeRTCDgAYJ_AwOcKCAQXgq-T7pR3rfWt7O9rR63pfele5Vo8WeVtOZtTBopPLzfr88ykquBAbpPsSnWEi8wINrt13zg91E7rwszDWsbEJX5Gr0OCbTvs9WttBj87Ytp1a7VGhvWl612l0si6KU9T0SKOibnobnxrcEKGxcf3j5EGl22CfHM7j5Or8_aZYpxefPnwszi5SwyQb063BQoMotSBbQw0vBZWMYJNjDFpmmdxqQTOOrRGSmCrDZZWbMjeRzAyRJT1O3i26w7TtbGlsH31o1WF45XSj_qz0Ta2u3TeVYc6yXEaB1wcB724mG0bVNWHeVvfWTUEJYEIQmv8XJCAoUIEj-OovcOcm30cXFOGcg8Cc00i9_CeFKeQxGrMUXiDjXQjeVneLYVBziNQSIjVf5xCp29jz_HdHfnUcUhOBZwuwC6Pzd3UiBY3jzY68WOqVdkpfxzyoqy8E4lAQPyGPCj8AkHnVkw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213085521</pqid></control><display><type>article</type><title>Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary Hepatocellular Carcinoma (HCC) in a Chinese population</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Mu, Li-Na ; Cao, Wei ; Zhang, Zuo-Feng ; Cai, Lin ; Jiang, Qing-Wu ; You, Nai-Chieh ; Goldstein, Binh Yang ; Wei, Guo-Rong ; Chen, Chuan-Wei ; Lu, Qing-Yi ; Zhou, Xue-Fu ; Ding, Bao-Guo ; Chang, Jun ; Yu, Shun-Zhang</creator><creatorcontrib>Mu, Li-Na ; Cao, Wei ; Zhang, Zuo-Feng ; Cai, Lin ; Jiang, Qing-Wu ; You, Nai-Chieh ; Goldstein, Binh Yang ; Wei, Guo-Rong ; Chen, Chuan-Wei ; Lu, Qing-Yi ; Zhou, Xue-Fu ; Ding, Bao-Guo ; Chang, Jun ; Yu, Shun-Zhang</creatorcontrib><description>Objectives Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors. Methods A population-based case-control study was conducted in Taixing, China. MTHFR C677T and A1298C were assayed by PCR-RFLP techniques. Results The frequency of MTHFR 677 C/C wild homozygotes genotype was 25.8% in cases, which was lower than that in controls (34.5%). The adjusted odds ratios (ORs) for the MTHFR 677 C/T and T/T genotype were 1.66(95% CI: 1.06-2.61), 1.21(95% CI: 0.65-2.28) respectively when compared with the MTHFR 677 C/C genotype. Subjects carrying any T genotype have the increased risk of 1.55(95% CI: 1.01-2.40) for development of primary hepatocellular carcinoma. A high degree of linkage disequilibrium was observed between the C677T and A1298C polymorphisms, with the D' of 0.887 and p < 0.01. The MTHFR 677 any T genotype was suggested to have potentially more than multiplicative interactions with raw water drinking with p-value for adjusted interaction of 0.03. Conclusion We observed that the MTHFR 677 C/T genotype was associated with an increased risk of primary liver cancer in a Chinese population. The polymorphism of MTHFR 677 might modify the effects of raw water drinking on the risk of primary hepatocellular carcinoma.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-007-9012-x</identifier><identifier>PMID: 17503006</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Netherlands: Dordrecht : Kluwer Academic Publishers</publisher><subject>Adult ; Aged ; Alcohol ; Alcohol drinking ; Cancer ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - genetics ; Case-Control Studies ; China - epidemiology ; Deoxyribonucleic acid ; DNA ; DNA biosynthesis ; DNA methylation ; Drinking ; Drinking water ; Effect modification ; Environmental risk ; Enzymes ; Epidemiology ; Female ; Gene polymorphism ; genetic polymorphism ; Genetic Predisposition to Disease ; Genotype & phenotype ; Genotypes ; Hepatitis antigens ; Hepatitis C ; Hepatocellular carcinoma ; Homocysteine ; Homozygotes ; Humans ; Infections ; Linkage disequilibrium ; Liver ; Liver cancer ; Liver diseases ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Liver Neoplasms - genetics ; Male ; Metabolism ; Methylenetetrahydrofolate reductase ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; MTHFR (5, 10-methylenetetralydrofolate reductase) ; P values ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Population ; Population studies ; Predisposing factors ; Primary liver cancer ; Public health ; Raw water ; Reductases ; Restriction fragment length polymorphism ; Risk analysis ; Risk Factors ; Vegetables</subject><ispartof>Cancer causes & control, 2007-08, Vol.18 (6), p.665-675</ispartof><rights>Copyright 2007 Springer Science+Business Media B.V.</rights><rights>Springer Science + Business Media B.V. 2007</rights><rights>Springer Science + Business Media B.V. 2007.</rights><rights>Springer Science+Business Media B.V. 2007 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-bc17a07da72bc3c6d739521c8110a9449ba73461ec792cf41df8cd8cc6d4c29d3</citedby><cites>FETCH-LOGICAL-c595t-bc17a07da72bc3c6d739521c8110a9449ba73461ec792cf41df8cd8cc6d4c29d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29736669$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29736669$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17503006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mu, Li-Na</creatorcontrib><creatorcontrib>Cao, Wei</creatorcontrib><creatorcontrib>Zhang, Zuo-Feng</creatorcontrib><creatorcontrib>Cai, Lin</creatorcontrib><creatorcontrib>Jiang, Qing-Wu</creatorcontrib><creatorcontrib>You, Nai-Chieh</creatorcontrib><creatorcontrib>Goldstein, Binh Yang</creatorcontrib><creatorcontrib>Wei, Guo-Rong</creatorcontrib><creatorcontrib>Chen, Chuan-Wei</creatorcontrib><creatorcontrib>Lu, Qing-Yi</creatorcontrib><creatorcontrib>Zhou, Xue-Fu</creatorcontrib><creatorcontrib>Ding, Bao-Guo</creatorcontrib><creatorcontrib>Chang, Jun</creatorcontrib><creatorcontrib>Yu, Shun-Zhang</creatorcontrib><title>Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary Hepatocellular Carcinoma (HCC) in a Chinese population</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>Objectives Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors. Methods A population-based case-control study was conducted in Taixing, China. MTHFR C677T and A1298C were assayed by PCR-RFLP techniques. Results The frequency of MTHFR 677 C/C wild homozygotes genotype was 25.8% in cases, which was lower than that in controls (34.5%). The adjusted odds ratios (ORs) for the MTHFR 677 C/T and T/T genotype were 1.66(95% CI: 1.06-2.61), 1.21(95% CI: 0.65-2.28) respectively when compared with the MTHFR 677 C/C genotype. Subjects carrying any T genotype have the increased risk of 1.55(95% CI: 1.01-2.40) for development of primary hepatocellular carcinoma. A high degree of linkage disequilibrium was observed between the C677T and A1298C polymorphisms, with the D' of 0.887 and p < 0.01. The MTHFR 677 any T genotype was suggested to have potentially more than multiplicative interactions with raw water drinking with p-value for adjusted interaction of 0.03. Conclusion We observed that the MTHFR 677 C/T genotype was associated with an increased risk of primary liver cancer in a Chinese population. The polymorphism of MTHFR 677 might modify the effects of raw water drinking on the risk of primary hepatocellular carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Alcohol drinking</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA biosynthesis</subject><subject>DNA methylation</subject><subject>Drinking</subject><subject>Drinking water</subject><subject>Effect modification</subject><subject>Environmental risk</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>genetic polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Hepatitis antigens</subject><subject>Hepatitis C</subject><subject>Hepatocellular carcinoma</subject><subject>Homocysteine</subject><subject>Homozygotes</subject><subject>Humans</subject><subject>Infections</subject><subject>Linkage disequilibrium</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - genetics</subject><subject>Male</subject><subject>Metabolism</subject><subject>Methylenetetrahydrofolate reductase</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>MTHFR (5, 10-methylenetetralydrofolate reductase)</subject><subject>P values</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Population</subject><subject>Population studies</subject><subject>Predisposing factors</subject><subject>Primary liver cancer</subject><subject>Public health</subject><subject>Raw water</subject><subject>Reductases</subject><subject>Restriction fragment length polymorphism</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Vegetables</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt-K1DAUxoso7rj6AF6oQUF2L6onSZM0N8JSXEfYRdDZ65BJ023Htukmrew8im9raof1D4hXCZzf-XLOly9JnmJ4gwHE24CBMZLGayoBk_T2XrLCTNBUEMLuJyuQTKSMZPQoeRTCDgAYJ_AwOcKCAQXgq-T7pR3rfWt7O9rR63pfele5Vo8WeVtOZtTBopPLzfr88ykquBAbpPsSnWEi8wINrt13zg91E7rwszDWsbEJX5Gr0OCbTvs9WttBj87Ytp1a7VGhvWl612l0si6KU9T0SKOibnobnxrcEKGxcf3j5EGl22CfHM7j5Or8_aZYpxefPnwszi5SwyQb063BQoMotSBbQw0vBZWMYJNjDFpmmdxqQTOOrRGSmCrDZZWbMjeRzAyRJT1O3i26w7TtbGlsH31o1WF45XSj_qz0Ta2u3TeVYc6yXEaB1wcB724mG0bVNWHeVvfWTUEJYEIQmv8XJCAoUIEj-OovcOcm30cXFOGcg8Cc00i9_CeFKeQxGrMUXiDjXQjeVneLYVBziNQSIjVf5xCp29jz_HdHfnUcUhOBZwuwC6Pzd3UiBY3jzY68WOqVdkpfxzyoqy8E4lAQPyGPCj8AkHnVkw</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Mu, Li-Na</creator><creator>Cao, Wei</creator><creator>Zhang, Zuo-Feng</creator><creator>Cai, Lin</creator><creator>Jiang, Qing-Wu</creator><creator>You, Nai-Chieh</creator><creator>Goldstein, Binh Yang</creator><creator>Wei, Guo-Rong</creator><creator>Chen, Chuan-Wei</creator><creator>Lu, Qing-Yi</creator><creator>Zhou, Xue-Fu</creator><creator>Ding, Bao-Guo</creator><creator>Chang, Jun</creator><creator>Yu, Shun-Zhang</creator><general>Dordrecht : Kluwer Academic Publishers</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070801</creationdate><title>Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary Hepatocellular Carcinoma (HCC) in a Chinese population</title><author>Mu, Li-Na ; Cao, Wei ; Zhang, Zuo-Feng ; Cai, Lin ; Jiang, Qing-Wu ; You, Nai-Chieh ; Goldstein, Binh Yang ; Wei, Guo-Rong ; Chen, Chuan-Wei ; Lu, Qing-Yi ; Zhou, Xue-Fu ; Ding, Bao-Guo ; Chang, Jun ; Yu, Shun-Zhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-bc17a07da72bc3c6d739521c8110a9449ba73461ec792cf41df8cd8cc6d4c29d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol</topic><topic>Alcohol drinking</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA biosynthesis</topic><topic>DNA methylation</topic><topic>Drinking</topic><topic>Drinking water</topic><topic>Effect modification</topic><topic>Environmental risk</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>genetic polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Hepatitis antigens</topic><topic>Hepatitis C</topic><topic>Hepatocellular carcinoma</topic><topic>Homocysteine</topic><topic>Homozygotes</topic><topic>Humans</topic><topic>Infections</topic><topic>Linkage disequilibrium</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver diseases</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - genetics</topic><topic>Male</topic><topic>Metabolism</topic><topic>Methylenetetrahydrofolate reductase</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>MTHFR (5, 10-methylenetetralydrofolate reductase)</topic><topic>P values</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Population</topic><topic>Population studies</topic><topic>Predisposing factors</topic><topic>Primary liver cancer</topic><topic>Public health</topic><topic>Raw water</topic><topic>Reductases</topic><topic>Restriction fragment length polymorphism</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mu, Li-Na</creatorcontrib><creatorcontrib>Cao, Wei</creatorcontrib><creatorcontrib>Zhang, Zuo-Feng</creatorcontrib><creatorcontrib>Cai, Lin</creatorcontrib><creatorcontrib>Jiang, Qing-Wu</creatorcontrib><creatorcontrib>You, Nai-Chieh</creatorcontrib><creatorcontrib>Goldstein, Binh Yang</creatorcontrib><creatorcontrib>Wei, Guo-Rong</creatorcontrib><creatorcontrib>Chen, Chuan-Wei</creatorcontrib><creatorcontrib>Lu, Qing-Yi</creatorcontrib><creatorcontrib>Zhou, Xue-Fu</creatorcontrib><creatorcontrib>Ding, Bao-Guo</creatorcontrib><creatorcontrib>Chang, Jun</creatorcontrib><creatorcontrib>Yu, Shun-Zhang</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Nucleic Acids Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mu, Li-Na</au><au>Cao, Wei</au><au>Zhang, Zuo-Feng</au><au>Cai, Lin</au><au>Jiang, Qing-Wu</au><au>You, Nai-Chieh</au><au>Goldstein, Binh Yang</au><au>Wei, Guo-Rong</au><au>Chen, Chuan-Wei</au><au>Lu, Qing-Yi</au><au>Zhou, Xue-Fu</au><au>Ding, Bao-Guo</au><au>Chang, Jun</au><au>Yu, Shun-Zhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary Hepatocellular Carcinoma (HCC) in a Chinese population</atitle><jtitle>Cancer causes & control</jtitle><addtitle>Cancer Causes Control</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>18</volume><issue>6</issue><spage>665</spage><epage>675</epage><pages>665-675</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Objectives Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors. Methods A population-based case-control study was conducted in Taixing, China. MTHFR C677T and A1298C were assayed by PCR-RFLP techniques. Results The frequency of MTHFR 677 C/C wild homozygotes genotype was 25.8% in cases, which was lower than that in controls (34.5%). The adjusted odds ratios (ORs) for the MTHFR 677 C/T and T/T genotype were 1.66(95% CI: 1.06-2.61), 1.21(95% CI: 0.65-2.28) respectively when compared with the MTHFR 677 C/C genotype. Subjects carrying any T genotype have the increased risk of 1.55(95% CI: 1.01-2.40) for development of primary hepatocellular carcinoma. A high degree of linkage disequilibrium was observed between the C677T and A1298C polymorphisms, with the D' of 0.887 and p < 0.01. The MTHFR 677 any T genotype was suggested to have potentially more than multiplicative interactions with raw water drinking with p-value for adjusted interaction of 0.03. Conclusion We observed that the MTHFR 677 C/T genotype was associated with an increased risk of primary liver cancer in a Chinese population. The polymorphism of MTHFR 677 might modify the effects of raw water drinking on the risk of primary hepatocellular carcinoma.</abstract><cop>Netherlands</cop><pub>Dordrecht : Kluwer Academic Publishers</pub><pmid>17503006</pmid><doi>10.1007/s10552-007-9012-x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4165489 |
| source | Jstor Complete Legacy; MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Alcohol Alcohol drinking Cancer Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - genetics Case-Control Studies China - epidemiology Deoxyribonucleic acid DNA DNA biosynthesis DNA methylation Drinking Drinking water Effect modification Environmental risk Enzymes Epidemiology Female Gene polymorphism genetic polymorphism Genetic Predisposition to Disease Genotype & phenotype Genotypes Hepatitis antigens Hepatitis C Hepatocellular carcinoma Homocysteine Homozygotes Humans Infections Linkage disequilibrium Liver Liver cancer Liver diseases Liver Neoplasms - epidemiology Liver Neoplasms - etiology Liver Neoplasms - genetics Male Metabolism Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged MTHFR (5, 10-methylenetetralydrofolate reductase) P values Polymorphism Polymorphism, Genetic Polymorphism, Restriction Fragment Length Population Population studies Predisposing factors Primary liver cancer Public health Raw water Reductases Restriction fragment length polymorphism Risk analysis Risk Factors Vegetables |
| title | Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary Hepatocellular Carcinoma (HCC) in a Chinese population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T18%3A36%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methylenetetrahydrofolate%20reductase%20(MTHFR)%20C677T%20and%20A1298C%20polymorphisms%20and%20the%20risk%20of%20primary%20Hepatocellular%20Carcinoma%20(HCC)%20in%20a%20Chinese%20population&rft.jtitle=Cancer%20causes%20&%20control&rft.au=Mu,%20Li-Na&rft.date=2007-08-01&rft.volume=18&rft.issue=6&rft.spage=665&rft.epage=675&rft.pages=665-675&rft.issn=0957-5243&rft.eissn=1573-7225&rft.coden=CCCNEN&rft_id=info:doi/10.1007/s10552-007-9012-x&rft_dat=%3Cjstor_pubme%3E29736669%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213085521&rft_id=info:pmid/17503006&rft_jstor_id=29736669&rfr_iscdi=true |