Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry
We report on the performance of structures for lossless ion manipulation (SLIM) as a means for transmitting ions and performing ion mobility separations (IMS). Ions were successfully transferred from an electrospray ionization (ESI) source to the TOF MS analyzer by means of a linear SLIM, demonstrat...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2014-09, Vol.86 (18), p.9169-9176 |
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| creator | Webb, Ian K Garimella, Sandilya V. B Tolmachev, Aleksey V Chen, Tsung-Chi Zhang, Xinyu Norheim, Randolph V Prost, Spencer A LaMarche, Brian Anderson, Gordon A Ibrahim, Yehia M Smith, Richard D |
| description | We report on the performance of structures for lossless ion manipulation (SLIM) as a means for transmitting ions and performing ion mobility separations (IMS). Ions were successfully transferred from an electrospray ionization (ESI) source to the TOF MS analyzer by means of a linear SLIM, demonstrating lossless ion transmission and an alternative arrangement including a 90° turn. First, the linear geometry was optimized for radial confinement by tuning RF on the central “rung” electrodes and potentials on the DC-only guard electrodes. Selecting an appropriate DC guard bias (2–6 V) and RF amplitude (≥160 Vp‑p at 750 kHz) resulted in the greatest ion intensities. Close to ideal IMS resolving power was maintained over a significant range of applied voltages. Second, the 90° turn was optimized for radial confinement by tuning RF on the rung electrodes and DC on the guard electrodes. However, both resolving power and ion transmission showed a dependence on these voltages, and the best conditions for both were >300 Vp‑p RF (685 kHz) and 7–11 V guard DC bias. Both geometries provide IMS resolving powers at the theoretical limit (R ∼ 58), showing that degraded resolution from a “racetrack” effect from turning around a corner can be successfully avoided, and the capability also was maintained for essentially lossless ion transmission. |
| doi_str_mv | 10.1021/ac502055e |
| format | Article |
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Selecting an appropriate DC guard bias (2–6 V) and RF amplitude (≥160 Vp‑p at 750 kHz) resulted in the greatest ion intensities. Close to ideal IMS resolving power was maintained over a significant range of applied voltages. Second, the 90° turn was optimized for radial confinement by tuning RF on the rung electrodes and DC on the guard electrodes. However, both resolving power and ion transmission showed a dependence on these voltages, and the best conditions for both were >300 Vp‑p RF (685 kHz) and 7–11 V guard DC bias. 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Both geometries provide IMS resolving powers at the theoretical limit (R ∼ 58), showing that degraded resolution from a “racetrack” effect from turning around a corner can be successfully avoided, and the capability also was maintained for essentially lossless ion transmission.</description><subject>Direct current</subject><subject>Electric potential</subject><subject>Electricity</subject><subject>Electrodes</subject><subject>Geometry</subject><subject>Guards</subject><subject>Ionic mobility</subject><subject>Ions</subject><subject>Ions - chemistry</subject><subject>Lossless</subject><subject>Mass spectrometry</subject><subject>Radio Waves</subject><subject>Resolution</subject><subject>Scientific imaging</subject><subject>Spectrometry, Mass, Electrospray Ionization - instrumentation</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Tuning</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>N~.</sourceid><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS0EokNhwQsgC4QEi4B_YifZVELVFCoN6qJlbTnOTceVJw62UxjehLfF05TRAAtWlny_e67v8UHoOSXvKGH0vTaCMCIEPEALKhgpZF2zh2hBCOEFqwg5Qk9ivCGEUkLlY3TExA6TcoF-Lr-PEOwGhqQdXt5qN-lk_YD10OGLMdmN_TFf-B5fpjCZNAWIuPcBr3yMDmLE57n8WQ92nNwdO5fvbn1rnU1bfDmCScFvIIUt_mbTGl_loYXvizNnr9cp92ehQ-opetRrF-HZ_XmMvpwtr04_FauLj-enH1aFLkkNBfCy74FWTJa6rg2lwjSllLyre0YpGA0dmKaTFW8lL9taVpo3omUt5H4KNT9GJ7PuOLUb6Ex2IminxmyKDlvltVV_Vga7Vtf-VpVUirJsssDLWcDHZFU0NoFZGz8MeReV31NWgmfozf2U4L9OEJPa2GjAOT2An6KismG8FpUk_0eFZFJSTllGX_2F3vgpDNmuHcUrRnMSMvV2pkzIPxag3y9HidoFSO0DlNkXh27syd-JycDrGdAmHkz7R-gXjkfPQw</recordid><startdate>20140916</startdate><enddate>20140916</enddate><creator>Webb, Ian K</creator><creator>Garimella, Sandilya V. 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B</au><au>Tolmachev, Aleksey V</au><au>Chen, Tsung-Chi</au><au>Zhang, Xinyu</au><au>Norheim, Randolph V</au><au>Prost, Spencer A</au><au>LaMarche, Brian</au><au>Anderson, Gordon A</au><au>Ibrahim, Yehia M</au><au>Smith, Richard D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2014-09-16</date><risdate>2014</risdate><volume>86</volume><issue>18</issue><spage>9169</spage><epage>9176</epage><pages>9169-9176</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>We report on the performance of structures for lossless ion manipulation (SLIM) as a means for transmitting ions and performing ion mobility separations (IMS). Ions were successfully transferred from an electrospray ionization (ESI) source to the TOF MS analyzer by means of a linear SLIM, demonstrating lossless ion transmission and an alternative arrangement including a 90° turn. First, the linear geometry was optimized for radial confinement by tuning RF on the central “rung” electrodes and potentials on the DC-only guard electrodes. Selecting an appropriate DC guard bias (2–6 V) and RF amplitude (≥160 Vp‑p at 750 kHz) resulted in the greatest ion intensities. Close to ideal IMS resolving power was maintained over a significant range of applied voltages. Second, the 90° turn was optimized for radial confinement by tuning RF on the rung electrodes and DC on the guard electrodes. However, both resolving power and ion transmission showed a dependence on these voltages, and the best conditions for both were >300 Vp‑p RF (685 kHz) and 7–11 V guard DC bias. Both geometries provide IMS resolving powers at the theoretical limit (R ∼ 58), showing that degraded resolution from a “racetrack” effect from turning around a corner can be successfully avoided, and the capability also was maintained for essentially lossless ion transmission.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>25152066</pmid><doi>10.1021/ac502055e</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Direct current Electric potential Electricity Electrodes Geometry Guards Ionic mobility Ions Ions - chemistry Lossless Mass spectrometry Radio Waves Resolution Scientific imaging Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods Tuning |
| title | Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry |
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