TH17 Cell Differentiation Is Regulated by the Circadian Clock

Circadian clocks regulate numerous physiological processes that vary across the day-night (diurnal) cycle, but if and how the circadian clock regulates the adaptive immune system is mostly unclear. lnterleukin-17–producing CD4⁺ T helper (T H 17) cells are proinflammatory immune cells that protect ag...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-11, Vol.342 (6159), p.727-730
Hauptverfasser:	Yu, Xiaofei, Rollins, Darcy, Ruhn, Kelly A., Stubblefield, Jeremy J., Green, Carla B., Kashiwada, Masaki, Rothman, Paul B., Takahashi, Joseph S., Hooper, Lora V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies autoimmune diseases Bacteria bacterial infections Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Biological clocks Biological rhythms CD4-positive T-lymphocytes Cell differentiation Cell Differentiation - genetics Cell Lineage - genetics Cell lines Cells Cellular biology Cellular immunity Circadian Clocks - genetics Circadian Clocks - immunology Circadian rhythm CLOCK Proteins - genetics Cytokines Differentiation environmental factors Environmental Influences fungi Gene Expression Regulation Germ-Free Life HEK293 Cells Humans Illumination immune response Immunology Individualized Instruction inflammatory bowel disease interleukin-17 Intestine, Small - immunology Intestine, Small - microbiology Intestines Journalism Jurkat Cells Lighting Mice Mice, Inbred C57BL Mice, Mutant Strains Microbiota Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nutrition Physiological regulation Promoter Regions, Genetic T lymphocytes Th17 Cells - cytology
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