Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418

Psychostimulant effects of cocaine are mediated partly by agonist actions at sigma-1 (σ1) receptors. Selective σ1 receptor antagonists attenuate these effects and provide a potential avenue for pharmacotherapy. However, the selective and high affinity σ1 antagonist PD144418 (1,2,3,6-tetrahydro-5-[3-...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-10, Vol.351 (1), p.153-163
Hauptverfasser:	Lever, John R, Miller, Dennis K, Fergason-Cantrell, Emily A, Green, Caroline L, Watkinson, Lisa D, Carmack, Terry L, Lever, Susan Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral Pharmacology Binding Sites Cocaine - pharmacology Dopamine Plasma Membrane Transport Proteins - metabolism Guinea Pigs Hyperkinesis - metabolism Isoxazoles - chemistry Isoxazoles - pharmacokinetics Isoxazoles - pharmacology Locomotion - drug effects Male Mice Motor Cortex - drug effects Motor Cortex - metabolism Narcotic Antagonists - pharmacokinetics Narcotic Antagonists - pharmacology Norepinephrine Plasma Membrane Transport Proteins - metabolism Protein Binding Pyridines - chemistry Pyridines - pharmacokinetics Pyridines - pharmacology Receptors, sigma - antagonists & inhibitors Receptors, sigma - chemistry Receptors, sigma - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Sigma-1 Receptor
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