Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis
Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% o...
Gespeichert in:
| Veröffentlicht in: | Endocrinology (Philadelphia) 2014-10, Vol.155 (10), p.4061-4068 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4068 |
|---|---|
| container_issue | 10 |
| container_start_page | 4061 |
| container_title | Endocrinology (Philadelphia) |
| container_volume | 155 |
| creator | Castroneves, Luciana A Jugo, Rebecca H Maynard, Michelle A Lee, Jennifer S Wassner, Ari J Dorfman, David Bronson, Roderick T Ukomadu, Chinweike Agoston, Agoston T Ding, Lai Luongo, Cristina Guo, Cuicui Song, Huaidong Demchev, Valeriy Lee, Nicholas Y Feldman, Henry A Vella, Kristen R Peake, Roy W Hartigan, Christina Kellogg, Mark D Desai, Anal Salvatore, Domenico Dentice, Monica Huang, Stephen A |
| description | Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (termed the low T3 syndrome). Here we show that a novel mutant mouse with hepatocyte-specific D3 deficiency has normal local responses to toxin-induced hepatonecrosis, including normal degrees of tissue necrosis and intact regeneration, but accelerated systemic recovery from illness-induced hypothyroxinemia and hypotriiodothyroninemia, demonstrating that peripheral D3 expression is a key modulator of the low T3 syndrome. |
| doi_str_mv | 10.1210/en.2013-2028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4164928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/en.2013-2028</oup_id><sourcerecordid>3130625814</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-25b1183d11388b139fb3fa52aaf0de7e9c815569f3c1557262596f7071bee3083</originalsourceid><addsrcrecordid>eNp1kU-P0zAQxS0EYsvCjTOyxIHLZvGfpEkuSNWySysVkKCIo-U4461XqR1spyJfi0-Io5QFJLh45Jmf3zzrIfSckkvKKHkN9pIRyjNGWPUALWidF1lJS_IQLcjULxkrz9CTEO7SNc9z_hidsYKQnNRkgX68NwrwVxP3eA29jE6NEbLPPSijjcJvIZ0GrBqx03g39oB5ahrXGisD4LU8At7YKFXEW3MEjz_BLVjwMhpnsbQtXikF3dSANg2VS9CIb7w74A_Oxv3onWllhzddZyEEvNIxqezcd2OzjW0HlZ7Nziwo74IJT9EjLbsAz071HH25ud5drbPtx3ebq9U2U3lVxYwVDaUVbynlVdVQXuuGa1kwKTVpoYRaVbQolrXmKtWSLVlRL3VJStoAcFLxc_Rm1u2H5gCtAhu97ETvzUH6UThpxN8Ta_bi1h1FTpd5zSaBlycB774NEKK4c4O3ybPglJO0sKJ5oi5mavpd8KDvN1AipoQFWDElLKaEE_7iT1f38K9IE_BqBtzQ_08qO0nxmQTbOuWNhd6nCH67_KeBn3JJwWA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3130625814</pqid></control><display><type>article</type><title>Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Castroneves, Luciana A ; Jugo, Rebecca H ; Maynard, Michelle A ; Lee, Jennifer S ; Wassner, Ari J ; Dorfman, David ; Bronson, Roderick T ; Ukomadu, Chinweike ; Agoston, Agoston T ; Ding, Lai ; Luongo, Cristina ; Guo, Cuicui ; Song, Huaidong ; Demchev, Valeriy ; Lee, Nicholas Y ; Feldman, Henry A ; Vella, Kristen R ; Peake, Roy W ; Hartigan, Christina ; Kellogg, Mark D ; Desai, Anal ; Salvatore, Domenico ; Dentice, Monica ; Huang, Stephen A</creator><creatorcontrib>Castroneves, Luciana A ; Jugo, Rebecca H ; Maynard, Michelle A ; Lee, Jennifer S ; Wassner, Ari J ; Dorfman, David ; Bronson, Roderick T ; Ukomadu, Chinweike ; Agoston, Agoston T ; Ding, Lai ; Luongo, Cristina ; Guo, Cuicui ; Song, Huaidong ; Demchev, Valeriy ; Lee, Nicholas Y ; Feldman, Henry A ; Vella, Kristen R ; Peake, Roy W ; Hartigan, Christina ; Kellogg, Mark D ; Desai, Anal ; Salvatore, Domenico ; Dentice, Monica ; Huang, Stephen A</creatorcontrib><description>Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (termed the low T3 syndrome). Here we show that a novel mutant mouse with hepatocyte-specific D3 deficiency has normal local responses to toxin-induced hepatonecrosis, including normal degrees of tissue necrosis and intact regeneration, but accelerated systemic recovery from illness-induced hypothyroxinemia and hypotriiodothyroninemia, demonstrating that peripheral D3 expression is a key modulator of the low T3 syndrome.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2013-2028</identifier><identifier>PMID: 25004090</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Animals ; Carbon Tetrachloride ; Chemical and Drug Induced Liver Injury - genetics ; Chemical and Drug Induced Liver Injury - physiopathology ; Chemical and Drug Induced Liver Injury - rehabilitation ; Female ; Hepatocytes - metabolism ; Hormones ; Illnesses ; Iodide peroxidase ; Iodide Peroxidase - deficiency ; Iodide Peroxidase - genetics ; Liver - drug effects ; Liver - pathology ; Liver Regeneration - genetics ; Male ; Mice ; Mice, Knockout ; Necrosis ; Necrosis - chemically induced ; Necrosis - genetics ; Organ Specificity - genetics ; Recovery ; Recovery of Function - genetics ; Regeneration ; Thyroid ; Thyroid gland ; Thyroid hormones ; Thyroid-TRH-TSH ; Toxins ; Toxins, Biological ; Triiodothyronine</subject><ispartof>Endocrinology (Philadelphia), 2014-10, Vol.155 (10), p.4061-4068</ispartof><rights>Copyright © 2014 by the Endocrine Society</rights><rights>Copyright © 2014 by the Endocrine Society 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-25b1183d11388b139fb3fa52aaf0de7e9c815569f3c1557262596f7071bee3083</citedby><cites>FETCH-LOGICAL-c488t-25b1183d11388b139fb3fa52aaf0de7e9c815569f3c1557262596f7071bee3083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25004090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castroneves, Luciana A</creatorcontrib><creatorcontrib>Jugo, Rebecca H</creatorcontrib><creatorcontrib>Maynard, Michelle A</creatorcontrib><creatorcontrib>Lee, Jennifer S</creatorcontrib><creatorcontrib>Wassner, Ari J</creatorcontrib><creatorcontrib>Dorfman, David</creatorcontrib><creatorcontrib>Bronson, Roderick T</creatorcontrib><creatorcontrib>Ukomadu, Chinweike</creatorcontrib><creatorcontrib>Agoston, Agoston T</creatorcontrib><creatorcontrib>Ding, Lai</creatorcontrib><creatorcontrib>Luongo, Cristina</creatorcontrib><creatorcontrib>Guo, Cuicui</creatorcontrib><creatorcontrib>Song, Huaidong</creatorcontrib><creatorcontrib>Demchev, Valeriy</creatorcontrib><creatorcontrib>Lee, Nicholas Y</creatorcontrib><creatorcontrib>Feldman, Henry A</creatorcontrib><creatorcontrib>Vella, Kristen R</creatorcontrib><creatorcontrib>Peake, Roy W</creatorcontrib><creatorcontrib>Hartigan, Christina</creatorcontrib><creatorcontrib>Kellogg, Mark D</creatorcontrib><creatorcontrib>Desai, Anal</creatorcontrib><creatorcontrib>Salvatore, Domenico</creatorcontrib><creatorcontrib>Dentice, Monica</creatorcontrib><creatorcontrib>Huang, Stephen A</creatorcontrib><title>Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (termed the low T3 syndrome). Here we show that a novel mutant mouse with hepatocyte-specific D3 deficiency has normal local responses to toxin-induced hepatonecrosis, including normal degrees of tissue necrosis and intact regeneration, but accelerated systemic recovery from illness-induced hypothyroxinemia and hypotriiodothyroninemia, demonstrating that peripheral D3 expression is a key modulator of the low T3 syndrome.</description><subject>Animals</subject><subject>Carbon Tetrachloride</subject><subject>Chemical and Drug Induced Liver Injury - genetics</subject><subject>Chemical and Drug Induced Liver Injury - physiopathology</subject><subject>Chemical and Drug Induced Liver Injury - rehabilitation</subject><subject>Female</subject><subject>Hepatocytes - metabolism</subject><subject>Hormones</subject><subject>Illnesses</subject><subject>Iodide peroxidase</subject><subject>Iodide Peroxidase - deficiency</subject><subject>Iodide Peroxidase - genetics</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver Regeneration - genetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Necrosis</subject><subject>Necrosis - chemically induced</subject><subject>Necrosis - genetics</subject><subject>Organ Specificity - genetics</subject><subject>Recovery</subject><subject>Recovery of Function - genetics</subject><subject>Regeneration</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid-TRH-TSH</subject><subject>Toxins</subject><subject>Toxins, Biological</subject><subject>Triiodothyronine</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU-P0zAQxS0EYsvCjTOyxIHLZvGfpEkuSNWySysVkKCIo-U4461XqR1spyJfi0-Io5QFJLh45Jmf3zzrIfSckkvKKHkN9pIRyjNGWPUALWidF1lJS_IQLcjULxkrz9CTEO7SNc9z_hidsYKQnNRkgX68NwrwVxP3eA29jE6NEbLPPSijjcJvIZ0GrBqx03g39oB5ahrXGisD4LU8At7YKFXEW3MEjz_BLVjwMhpnsbQtXikF3dSANg2VS9CIb7w74A_Oxv3onWllhzddZyEEvNIxqezcd2OzjW0HlZ7Nziwo74IJT9EjLbsAz071HH25ud5drbPtx3ebq9U2U3lVxYwVDaUVbynlVdVQXuuGa1kwKTVpoYRaVbQolrXmKtWSLVlRL3VJStoAcFLxc_Rm1u2H5gCtAhu97ETvzUH6UThpxN8Ta_bi1h1FTpd5zSaBlycB774NEKK4c4O3ybPglJO0sKJ5oi5mavpd8KDvN1AipoQFWDElLKaEE_7iT1f38K9IE_BqBtzQ_08qO0nxmQTbOuWNhd6nCH67_KeBn3JJwWA</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Castroneves, Luciana A</creator><creator>Jugo, Rebecca H</creator><creator>Maynard, Michelle A</creator><creator>Lee, Jennifer S</creator><creator>Wassner, Ari J</creator><creator>Dorfman, David</creator><creator>Bronson, Roderick T</creator><creator>Ukomadu, Chinweike</creator><creator>Agoston, Agoston T</creator><creator>Ding, Lai</creator><creator>Luongo, Cristina</creator><creator>Guo, Cuicui</creator><creator>Song, Huaidong</creator><creator>Demchev, Valeriy</creator><creator>Lee, Nicholas Y</creator><creator>Feldman, Henry A</creator><creator>Vella, Kristen R</creator><creator>Peake, Roy W</creator><creator>Hartigan, Christina</creator><creator>Kellogg, Mark D</creator><creator>Desai, Anal</creator><creator>Salvatore, Domenico</creator><creator>Dentice, Monica</creator><creator>Huang, Stephen A</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis</title><author>Castroneves, Luciana A ; Jugo, Rebecca H ; Maynard, Michelle A ; Lee, Jennifer S ; Wassner, Ari J ; Dorfman, David ; Bronson, Roderick T ; Ukomadu, Chinweike ; Agoston, Agoston T ; Ding, Lai ; Luongo, Cristina ; Guo, Cuicui ; Song, Huaidong ; Demchev, Valeriy ; Lee, Nicholas Y ; Feldman, Henry A ; Vella, Kristen R ; Peake, Roy W ; Hartigan, Christina ; Kellogg, Mark D ; Desai, Anal ; Salvatore, Domenico ; Dentice, Monica ; Huang, Stephen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-25b1183d11388b139fb3fa52aaf0de7e9c815569f3c1557262596f7071bee3083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Carbon Tetrachloride</topic><topic>Chemical and Drug Induced Liver Injury - genetics</topic><topic>Chemical and Drug Induced Liver Injury - physiopathology</topic><topic>Chemical and Drug Induced Liver Injury - rehabilitation</topic><topic>Female</topic><topic>Hepatocytes - metabolism</topic><topic>Hormones</topic><topic>Illnesses</topic><topic>Iodide peroxidase</topic><topic>Iodide Peroxidase - deficiency</topic><topic>Iodide Peroxidase - genetics</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Liver Regeneration - genetics</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Necrosis</topic><topic>Necrosis - chemically induced</topic><topic>Necrosis - genetics</topic><topic>Organ Specificity - genetics</topic><topic>Recovery</topic><topic>Recovery of Function - genetics</topic><topic>Regeneration</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid-TRH-TSH</topic><topic>Toxins</topic><topic>Toxins, Biological</topic><topic>Triiodothyronine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castroneves, Luciana A</creatorcontrib><creatorcontrib>Jugo, Rebecca H</creatorcontrib><creatorcontrib>Maynard, Michelle A</creatorcontrib><creatorcontrib>Lee, Jennifer S</creatorcontrib><creatorcontrib>Wassner, Ari J</creatorcontrib><creatorcontrib>Dorfman, David</creatorcontrib><creatorcontrib>Bronson, Roderick T</creatorcontrib><creatorcontrib>Ukomadu, Chinweike</creatorcontrib><creatorcontrib>Agoston, Agoston T</creatorcontrib><creatorcontrib>Ding, Lai</creatorcontrib><creatorcontrib>Luongo, Cristina</creatorcontrib><creatorcontrib>Guo, Cuicui</creatorcontrib><creatorcontrib>Song, Huaidong</creatorcontrib><creatorcontrib>Demchev, Valeriy</creatorcontrib><creatorcontrib>Lee, Nicholas Y</creatorcontrib><creatorcontrib>Feldman, Henry A</creatorcontrib><creatorcontrib>Vella, Kristen R</creatorcontrib><creatorcontrib>Peake, Roy W</creatorcontrib><creatorcontrib>Hartigan, Christina</creatorcontrib><creatorcontrib>Kellogg, Mark D</creatorcontrib><creatorcontrib>Desai, Anal</creatorcontrib><creatorcontrib>Salvatore, Domenico</creatorcontrib><creatorcontrib>Dentice, Monica</creatorcontrib><creatorcontrib>Huang, Stephen A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castroneves, Luciana A</au><au>Jugo, Rebecca H</au><au>Maynard, Michelle A</au><au>Lee, Jennifer S</au><au>Wassner, Ari J</au><au>Dorfman, David</au><au>Bronson, Roderick T</au><au>Ukomadu, Chinweike</au><au>Agoston, Agoston T</au><au>Ding, Lai</au><au>Luongo, Cristina</au><au>Guo, Cuicui</au><au>Song, Huaidong</au><au>Demchev, Valeriy</au><au>Lee, Nicholas Y</au><au>Feldman, Henry A</au><au>Vella, Kristen R</au><au>Peake, Roy W</au><au>Hartigan, Christina</au><au>Kellogg, Mark D</au><au>Desai, Anal</au><au>Salvatore, Domenico</au><au>Dentice, Monica</au><au>Huang, Stephen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>155</volume><issue>10</issue><spage>4061</spage><epage>4068</epage><pages>4061-4068</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><abstract>Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (termed the low T3 syndrome). Here we show that a novel mutant mouse with hepatocyte-specific D3 deficiency has normal local responses to toxin-induced hepatonecrosis, including normal degrees of tissue necrosis and intact regeneration, but accelerated systemic recovery from illness-induced hypothyroxinemia and hypotriiodothyroninemia, demonstrating that peripheral D3 expression is a key modulator of the low T3 syndrome.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>25004090</pmid><doi>10.1210/en.2013-2028</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-7227 |
| ispartof | Endocrinology (Philadelphia), 2014-10, Vol.155 (10), p.4061-4068 |
| issn | 0013-7227 1945-7170 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4164928 |
| source | MEDLINE; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Carbon Tetrachloride Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - physiopathology Chemical and Drug Induced Liver Injury - rehabilitation Female Hepatocytes - metabolism Hormones Illnesses Iodide peroxidase Iodide Peroxidase - deficiency Iodide Peroxidase - genetics Liver - drug effects Liver - pathology Liver Regeneration - genetics Male Mice Mice, Knockout Necrosis Necrosis - chemically induced Necrosis - genetics Organ Specificity - genetics Recovery Recovery of Function - genetics Regeneration Thyroid Thyroid gland Thyroid hormones Thyroid-TRH-TSH Toxins Toxins, Biological Triiodothyronine |
| title | Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T07%3A36%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mice%20With%20Hepatocyte-Specific%20Deficiency%20of%20Type%203%20Deiodinase%20Have%20Intact%20Liver%20Regeneration%20and%20Accelerated%20Recovery%20From%20Nonthyroidal%20Illness%20After%20Toxin-Induced%20Hepatonecrosis&rft.jtitle=Endocrinology%20(Philadelphia)&rft.au=Castroneves,%20Luciana%20A&rft.date=2014-10-01&rft.volume=155&rft.issue=10&rft.spage=4061&rft.epage=4068&rft.pages=4061-4068&rft.issn=0013-7227&rft.eissn=1945-7170&rft_id=info:doi/10.1210/en.2013-2028&rft_dat=%3Cproquest_pubme%3E3130625814%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3130625814&rft_id=info:pmid/25004090&rft_oup_id=10.1210/en.2013-2028&rfr_iscdi=true |