7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells

7-Ketocholesterol (7-KC) is found at an elevated level in patients with cancer and chronic liver disease. The up-regulation of an efflux pump, P-glycoprotein (P-gp) leads to drug resistance. To elucidate the effect of 7-KC on P-gp, P-gp function and expression were investigated in hepatoma cell line...

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Veröffentlicht in:	Biochemical pharmacology 2013-08, Vol.86 (4), p.548-560
Hauptverfasser:	Wang, Sheng-Fan, Chou, Yueh-Ching, Mazumder, Nirmal, Kao, Fu-Jen, Nagy, Leslie D., Guengerich, F. Peter, Huang, Cheng, Lee, Hsin-Chen, Lai, Ping-Shan, Ueng, Yune-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Ketocholesterol Acetylcysteine - pharmacology Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Antioxidants - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis Carcinoma, Hepatocellular Cell Line Cell Line, Tumor Cell Survival Cholesterol - pharmacology cysteine cytotoxicity doxorubicin Doxorubicin - metabolism Doxorubicin - pharmacology drug resistance Drug Resistance, Neoplasm fluorescence Glycolysis Hepatocytes - metabolism Hepatoma Humans Hydroxycholesterols - pharmacology Ketocholesterols - metabolism Ketocholesterols - pharmacology Lactic Acid - biosynthesis liver Oligomycins - pharmacology P-Glycoprotein patients phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors PI3K/mTOR protein synthesis Signal Transduction TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism transporters Up-Regulation
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