Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis

We investigated the therapeutic potential and mechanism of action of IFN-beta protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections of recombinant mouse IFN-beta or saline...

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Veröffentlicht in:	Arthritis research & therapy 2004-01, Vol.6 (3), p.R239-R249, Article R239
Hauptverfasser:	van Holten, Judith, Reedquist, Kris, Sattonet-Roche, Pascale, Smeets, Tom J M, Plater-Zyberk, Christine, Vervoordeldonk, Margriet J, Tak, Paul P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antirheumatic Agents - administration & dosage Antirheumatic Agents - therapeutic use Arthritis, Experimental - chemically induced Arthritis, Experimental - prevention & control Arthritis, Rheumatoid - pathology Cartilage - drug effects Cartilage - pathology Cartilage Diseases - prevention & control Collagen Type II - immunology Cytokines - metabolism Disease Models, Animal Drug Administration Schedule Fibroblasts - metabolism Fibroblasts - pathology Inflammation - prevention & control Interferon Type I - administration & dosage Interferon Type I - therapeutic use Male Mice Mice, Inbred DBA Osteoarthritis - pathology Osteoarthritis - prevention & control Recombinant Proteins Synovial Membrane - pathology
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