Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum

In this study, the authors show that there are multiple forms of opioid-induced long-term depression (OP-LTD) in the dorsal striatum, each mediated by the mu, delta or kappa opioid receptor. The mu and delta OP-LTD are presynaptic and can summate, but only mu OP-LTD occludes endocannabinoid-induced...

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Veröffentlicht in:	Nature neuroscience 2014-04, Vol.17 (4), p.540-548
Hauptverfasser:	Atwood, Brady K, Kupferschmidt, David A, Lovinger, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	13/44 631/378/2591/2593 9/30 9/74 Analgesics Analgesics, Opioid - administration & dosage Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedicine Corpus striatum Corpus Striatum - drug effects Corpus Striatum - metabolism Depression, Mental Drug abuse Endocannabinoids - metabolism Female Health aspects Long-Term Synaptic Depression - drug effects Long-Term Synaptic Depression - physiology Male Mice Mice, Inbred C57BL Narcotics Neurobiology Neuronal Plasticity - drug effects Neurosciences Opioid Peptides - metabolism Opioids Oxycodone - administration & dosage Peptides Physiological aspects Rats Rats, Sprague-Dawley Receptors, Opioid - drug effects Receptors, Opioid - metabolism Receptors, Opioid - physiology Receptors, Opioid, delta - drug effects Receptors, Opioid, delta - metabolism Receptors, Opioid, delta - physiology Receptors, Opioid, kappa - drug effects Receptors, Opioid, kappa - metabolism Receptors, Opioid, kappa - physiology Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Receptors, Opioid, mu - physiology Risk factors
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