Anticancer Activity of Marine Sponge Hyrtios sp. Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status

Drug development using marine bioresources is limited even though the ocean occupies about 70% of the earth and contains a large number of biological materials. From the screening test of the marine sponge extracts, we found Hyrtios sp. sponge collected from Chuuk island, Micronesia. In this study,...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-5
Hauptverfasser:	Jung, Joohee, Lee, Hyi-Seung, Bae, Woori, Lim, Hyun Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Aquatic Organisms - chemistry Biological activity Cancer Care and treatment Cell growth Cell Line, Tumor Cell Shape - drug effects Cell Survival - drug effects Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Complex Mixtures - pharmacology Complex Mixtures - toxicity Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cytotoxicity Humans Hyrtios JNK Mitogen-Activated Protein Kinases - metabolism Kinases Medical research Metabolites Mitosis - drug effects Phosphatase Physiological aspects Porifera - chemistry Protein expression Proteins Studies Tumor proteins Tumor Suppressor Protein p53 - metabolism
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