Anticancer Activity of Marine Sponge Hyrtios sp. Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status
Drug development using marine bioresources is limited even though the ocean occupies about 70% of the earth and contains a large number of biological materials. From the screening test of the marine sponge extracts, we found Hyrtios sp. sponge collected from Chuuk island, Micronesia. In this study,...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-5 |
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| creator | Jung, Joohee Lee, Hyi-Seung Bae, Woori Lim, Hyun Kyung |
| description | Drug development using marine bioresources is limited even though the ocean occupies about 70% of the earth and contains a large number of biological materials. From the screening test of the marine sponge extracts, we found Hyrtios sp. sponge collected from Chuuk island, Micronesia. In this study, the Hyrtios sp. extract was examined for anticancer activity against human colorectal carcinoma RKO cells that are wildtype for p53 and RKO-E6 that are p53 defective. The Hyrtios sp. extract dose-dependently inhibited viability in both cell lines. Multinucleation as an indication of mitotic catastrophe was also observed. Cytotoxicity tests gave significantly different results for RKO and RKO-E6 cells after 48 h exposure to Hyrtios sp. extract. In RKO cells treated with Hyrtios sp. extract, cell death occurred by induction of p53 and p21 proteins. In p53-defective RKO-E6 cells, Hyrtios sp. extract decreased expression of JNK protein and increased p21 protein. These results indicate that Hyrtios sp. extract induced apoptosis via different pathways depending on p53 status and could be a good natural product for developing new anticancer drugs. |
| doi_str_mv | 10.1155/2014/413575 |
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Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Jung, Joohee ; Lee, Hyi-Seung ; Bae, Woori ; Lim, Hyun Kyung</creator><contributor>Yang, Shun-Fa</contributor><creatorcontrib>Jung, Joohee ; Lee, Hyi-Seung ; Bae, Woori ; Lim, Hyun Kyung ; Yang, Shun-Fa</creatorcontrib><description>Drug development using marine bioresources is limited even though the ocean occupies about 70% of the earth and contains a large number of biological materials. From the screening test of the marine sponge extracts, we found Hyrtios sp. sponge collected from Chuuk island, Micronesia. In this study, the Hyrtios sp. extract was examined for anticancer activity against human colorectal carcinoma RKO cells that are wildtype for p53 and RKO-E6 that are p53 defective. The Hyrtios sp. extract dose-dependently inhibited viability in both cell lines. Multinucleation as an indication of mitotic catastrophe was also observed. Cytotoxicity tests gave significantly different results for RKO and RKO-E6 cells after 48 h exposure to Hyrtios sp. extract. In RKO cells treated with Hyrtios sp. extract, cell death occurred by induction of p53 and p21 proteins. In p53-defective RKO-E6 cells, Hyrtios sp. extract decreased expression of JNK protein and increased p21 protein. These results indicate that Hyrtios sp. extract induced apoptosis via different pathways depending on p53 status and could be a good natural product for developing new anticancer drugs.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/413575</identifier><identifier>PMID: 25243139</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - toxicity ; Apoptosis ; Apoptosis - drug effects ; Aquatic Organisms - chemistry ; Biological activity ; Cancer ; Care and treatment ; Cell growth ; Cell Line, Tumor ; Cell Shape - drug effects ; Cell Survival - drug effects ; Colorectal cancer ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Complex Mixtures - pharmacology ; Complex Mixtures - toxicity ; Cyclin-Dependent Kinase Inhibitor p21 - metabolism ; Cytotoxicity ; Humans ; Hyrtios ; JNK Mitogen-Activated Protein Kinases - metabolism ; Kinases ; Medical research ; Metabolites ; Mitosis - drug effects ; Phosphatase ; Physiological aspects ; Porifera - chemistry ; Protein expression ; Proteins ; Studies ; Tumor proteins ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-5</ispartof><rights>Copyright © 2014 Hyun Kyung Lim et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Hyun Kyung Lim et al. Hyun Kyung Lim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Hyun Kyung Lim et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-ebfebfd0a142ad6c39872627d159be4e683cec83d332afc6419c244458a9c9c93</citedby><cites>FETCH-LOGICAL-c491t-ebfebfd0a142ad6c39872627d159be4e683cec83d332afc6419c244458a9c9c93</cites><orcidid>0000-0001-9124-9052</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163483/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163483/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25243139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yang, Shun-Fa</contributor><creatorcontrib>Jung, Joohee</creatorcontrib><creatorcontrib>Lee, Hyi-Seung</creatorcontrib><creatorcontrib>Bae, Woori</creatorcontrib><creatorcontrib>Lim, Hyun Kyung</creatorcontrib><title>Anticancer Activity of Marine Sponge Hyrtios sp. Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Drug development using marine bioresources is limited even though the ocean occupies about 70% of the earth and contains a large number of biological materials. From the screening test of the marine sponge extracts, we found Hyrtios sp. sponge collected from Chuuk island, Micronesia. In this study, the Hyrtios sp. extract was examined for anticancer activity against human colorectal carcinoma RKO cells that are wildtype for p53 and RKO-E6 that are p53 defective. The Hyrtios sp. extract dose-dependently inhibited viability in both cell lines. Multinucleation as an indication of mitotic catastrophe was also observed. Cytotoxicity tests gave significantly different results for RKO and RKO-E6 cells after 48 h exposure to Hyrtios sp. extract. In RKO cells treated with Hyrtios sp. extract, cell death occurred by induction of p53 and p21 proteins. In p53-defective RKO-E6 cells, Hyrtios sp. extract decreased expression of JNK protein and increased p21 protein. These results indicate that Hyrtios sp. extract induced apoptosis via different pathways depending on p53 status and could be a good natural product for developing new anticancer drugs.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aquatic Organisms - chemistry</subject><subject>Biological activity</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Shape - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Complex Mixtures - pharmacology</subject><subject>Complex Mixtures - toxicity</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</subject><subject>Cytotoxicity</subject><subject>Humans</subject><subject>Hyrtios</subject><subject>JNK Mitogen-Activated Protein Kinases - metabolism</subject><subject>Kinases</subject><subject>Medical research</subject><subject>Metabolites</subject><subject>Mitosis - drug effects</subject><subject>Phosphatase</subject><subject>Physiological aspects</subject><subject>Porifera - chemistry</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Studies</subject><subject>Tumor proteins</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkd1rFDEUxQdRbKl98l0Cvoiy7dx8bfIiLGPripWC1eeQzWR2U2aSbZJp3f71Ztm6rD6ZBO6F_Djcc09VvYb6DICxc1wDPadA2JQ9q44xATrhQOH5vifkqDpN6bYuRwCvJX9ZHWGGKQEij6vHmc_OaG9sRDOT3b3LGxQ69E1H5y26WQe_tGi-idmFhNL6DF38ylGbjJxH83HQHjWhD9GarHvU6GicD4NG379eo8b2fUIPLq_QJ9d1Nlqf0ZoRdJN1HtOr6kWn-2RPn-pJ9fPy4kczn1xdf_7SzK4mhkrIE7voymtrDRTrlhsixRRzPG2ByYWllgtirBGkJQTrznAK0mBKKRNamnLJSfVxp7seF4NtTZki6l6toxt03Kignfr7x7uVWoZ7RYETKkgRePckEMPdaFNWg0ummNPehjEp4CCAEUl5Qd_-g96GMfpiTwHjteCCswNqqXurnO_CdqVbUTWjeFpjLJko1IcdZWJIKdpuPzLUahu-2oavduEX-s2hyz37J-oCvN8BK-db_eD-T80WxHb6AIaye0l-A33Sv0I</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Jung, Joohee</creator><creator>Lee, Hyi-Seung</creator><creator>Bae, Woori</creator><creator>Lim, Hyun Kyung</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TO</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9124-9052</orcidid></search><sort><creationdate>20140101</creationdate><title>Anticancer Activity of Marine Sponge Hyrtios sp. 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Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Drug development using marine bioresources is limited even though the ocean occupies about 70% of the earth and contains a large number of biological materials. From the screening test of the marine sponge extracts, we found Hyrtios sp. sponge collected from Chuuk island, Micronesia. In this study, the Hyrtios sp. extract was examined for anticancer activity against human colorectal carcinoma RKO cells that are wildtype for p53 and RKO-E6 that are p53 defective. The Hyrtios sp. extract dose-dependently inhibited viability in both cell lines. Multinucleation as an indication of mitotic catastrophe was also observed. Cytotoxicity tests gave significantly different results for RKO and RKO-E6 cells after 48 h exposure to Hyrtios sp. extract. In RKO cells treated with Hyrtios sp. extract, cell death occurred by induction of p53 and p21 proteins. In p53-defective RKO-E6 cells, Hyrtios sp. extract decreased expression of JNK protein and increased p21 protein. These results indicate that Hyrtios sp. extract induced apoptosis via different pathways depending on p53 status and could be a good natural product for developing new anticancer drugs.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25243139</pmid><doi>10.1155/2014/413575</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9124-9052</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Aquatic Organisms - chemistry Biological activity Cancer Care and treatment Cell growth Cell Line, Tumor Cell Shape - drug effects Cell Survival - drug effects Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Complex Mixtures - pharmacology Complex Mixtures - toxicity Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cytotoxicity Humans Hyrtios JNK Mitogen-Activated Protein Kinases - metabolism Kinases Medical research Metabolites Mitosis - drug effects Phosphatase Physiological aspects Porifera - chemistry Protein expression Proteins Studies Tumor proteins Tumor Suppressor Protein p53 - metabolism |
| title | Anticancer Activity of Marine Sponge Hyrtios sp. Extract in Human Colorectal Carcinoma RKO Cells with Different p53 Status |
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