The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology

Protein folding is a complex, error-prone process that often results in an irreparable protein by-product. These by-products can be recognized by cellular quality control machineries and targeted for proteasome-dependent degradation. The folding of proteins in the secretory pathway adds another laye...

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Veröffentlicht in:	Physiological reviews 2012-04, Vol.92 (2), p.537-576
Hauptverfasser:	Guerriero, Christopher J, Brodsky, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Endoplasmic Reticulum - metabolism Endoplasmic Reticulum-Associated Degradation - physiology Humans Medical treatment Pathogens Proteasome Endopeptidase Complex - metabolism Protein Folding Protein Processing, Post-Translational - physiology Proteins - secretion Proteostasis Deficiencies - metabolism Proteostasis Deficiencies - physiopathology Secretory Pathway - physiology Substrates
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