Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophages
Dictamnus dasycarpus is widely used as a traditional remedy for the treatment of eczema, rheumatism, and other inflammatory diseases in Asia. The current study investigates the molecular mechanism of anti-inflammatory action of the ethanol extract of Dictamnus dasycarpus leaf (DE) in lipopolysacchar...
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| Veröffentlicht in: | BMC complementary and alternative medicine 2014-09, Vol.14 (1), p.330-330, Article 330 |
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| creator | Ghosh, Chiranjit Hong, Bora Batabyal, Subhasis Jeon, Tae-Il Yang, Seung-Hak Hwang, Seong Gu |
| description | Dictamnus dasycarpus is widely used as a traditional remedy for the treatment of eczema, rheumatism, and other inflammatory diseases in Asia. The current study investigates the molecular mechanism of anti-inflammatory action of the ethanol extract of Dictamnus dasycarpus leaf (DE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Nitric oxide (NO) production was assessed by Griess reaction and the mRNA and protein expressions of pro inflammatory cytokines, transcription factor, and enzymes were determined by real-time RT-PCR and immunoblotting analysis.
DE (0.5 and 1 mg/mL) suppressed the NO production by 10 and 33%, respectively, compared to the untreated group in LPS-stimulated RAW 264.7 cells. DE (0.5 and 1 mg/mL) reduced the mRNA expression of key transcription factor nuclear factor-κB by 7 and 24%, respectively compared to the untreated group in LPS activated macrophage. The pro inflammatory cytokines such as tumor necrosis factor α and interleukin 1β were also decreased by DE treatment. Moreover, the protein expression of pro inflammatory enzymes, inducible nitric oxide synthase and cyclooxygenase 2 were also dramatically attenuated by DE in a dose dependent manner.
These results suggest that Dictamnus dasycarpus leaf has a potent anti-inflammatory activity and can be used for the development of new anti-inflammatory agents. |
| doi_str_mv | 10.1186/1472-6882-14-330 |
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Nitric oxide (NO) production was assessed by Griess reaction and the mRNA and protein expressions of pro inflammatory cytokines, transcription factor, and enzymes were determined by real-time RT-PCR and immunoblotting analysis.
DE (0.5 and 1 mg/mL) suppressed the NO production by 10 and 33%, respectively, compared to the untreated group in LPS-stimulated RAW 264.7 cells. DE (0.5 and 1 mg/mL) reduced the mRNA expression of key transcription factor nuclear factor-κB by 7 and 24%, respectively compared to the untreated group in LPS activated macrophage. The pro inflammatory cytokines such as tumor necrosis factor α and interleukin 1β were also decreased by DE treatment. Moreover, the protein expression of pro inflammatory enzymes, inducible nitric oxide synthase and cyclooxygenase 2 were also dramatically attenuated by DE in a dose dependent manner.
These results suggest that Dictamnus dasycarpus leaf has a potent anti-inflammatory activity and can be used for the development of new anti-inflammatory agents.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-14-330</identifier><identifier>PMID: 25182043</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Animal sciences ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Asia ; Cell culture ; Cell Line ; Chronic illnesses ; complement ; Cyclooxygenase 2 - genetics ; Cyclooxygenase 2 - immunology ; Cytokines - immunology ; Defense mechanisms ; Dictamnus - chemistry ; Dictamnus dasycarpus ; dose response ; Drug therapy ; eczema ; Environmental science ; Enzymes ; ethanol ; gene expression ; immunoblotting ; inducible nitric oxide synthase ; Inflammation ; interleukins ; leaves ; lipopolysaccharides ; Lipopolysaccharides - immunology ; macrophages ; Macrophages - drug effects ; Macrophages - immunology ; Medical research ; Medicine, Experimental ; Mice ; NF-kappa B - genetics ; NF-kappa B - immunology ; Nitric oxide ; Nitric Oxide - immunology ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - immunology ; Pathogenesis ; Physiological aspects ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; prostaglandin synthase ; Protein expression ; protein synthesis ; Proteins ; rheumatoid arthritis ; Rodents ; Rural development ; Studies ; transcription factors ; tumor necrosis factors ; Zoology</subject><ispartof>BMC complementary and alternative medicine, 2014-09, Vol.14 (1), p.330-330, Article 330</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Ghosh et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.</rights><rights>Ghosh et al.; licensee BioMed Central Ltd. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-48bbd7fe90404d667b3da9375e793491363e325d6d2b3dd4b4e3bf5959ca1a9f3</citedby><cites>FETCH-LOGICAL-c658t-48bbd7fe90404d667b3da9375e793491363e325d6d2b3dd4b4e3bf5959ca1a9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161857/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161857/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25182043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghosh, Chiranjit</creatorcontrib><creatorcontrib>Hong, Bora</creatorcontrib><creatorcontrib>Batabyal, Subhasis</creatorcontrib><creatorcontrib>Jeon, Tae-Il</creatorcontrib><creatorcontrib>Yang, Seung-Hak</creatorcontrib><creatorcontrib>Hwang, Seong Gu</creatorcontrib><title>Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophages</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Dictamnus dasycarpus is widely used as a traditional remedy for the treatment of eczema, rheumatism, and other inflammatory diseases in Asia. The current study investigates the molecular mechanism of anti-inflammatory action of the ethanol extract of Dictamnus dasycarpus leaf (DE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Nitric oxide (NO) production was assessed by Griess reaction and the mRNA and protein expressions of pro inflammatory cytokines, transcription factor, and enzymes were determined by real-time RT-PCR and immunoblotting analysis.
DE (0.5 and 1 mg/mL) suppressed the NO production by 10 and 33%, respectively, compared to the untreated group in LPS-stimulated RAW 264.7 cells. DE (0.5 and 1 mg/mL) reduced the mRNA expression of key transcription factor nuclear factor-κB by 7 and 24%, respectively compared to the untreated group in LPS activated macrophage. The pro inflammatory cytokines such as tumor necrosis factor α and interleukin 1β were also decreased by DE treatment. Moreover, the protein expression of pro inflammatory enzymes, inducible nitric oxide synthase and cyclooxygenase 2 were also dramatically attenuated by DE in a dose dependent manner.
These results suggest that Dictamnus dasycarpus leaf has a potent anti-inflammatory activity and can be used for the development of new anti-inflammatory agents.</description><subject>Analysis</subject><subject>Animal sciences</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Asia</subject><subject>Cell culture</subject><subject>Cell Line</subject><subject>Chronic illnesses</subject><subject>complement</subject><subject>Cyclooxygenase 2 - genetics</subject><subject>Cyclooxygenase 2 - immunology</subject><subject>Cytokines - immunology</subject><subject>Defense mechanisms</subject><subject>Dictamnus - chemistry</subject><subject>Dictamnus dasycarpus</subject><subject>dose response</subject><subject>Drug therapy</subject><subject>eczema</subject><subject>Environmental science</subject><subject>Enzymes</subject><subject>ethanol</subject><subject>gene expression</subject><subject>immunoblotting</subject><subject>inducible nitric oxide synthase</subject><subject>Inflammation</subject><subject>interleukins</subject><subject>leaves</subject><subject>lipopolysaccharides</subject><subject>Lipopolysaccharides - immunology</subject><subject>macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mice</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - immunology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - immunology</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Nitric Oxide Synthase Type II - immunology</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>prostaglandin synthase</subject><subject>Protein expression</subject><subject>protein synthesis</subject><subject>Proteins</subject><subject>rheumatoid arthritis</subject><subject>Rodents</subject><subject>Rural development</subject><subject>Studies</subject><subject>transcription factors</subject><subject>tumor necrosis factors</subject><subject>Zoology</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks-L1TAQx4so7rp69yQFQbx0TZo0TS_CY_0JC170HKbN9DVLmtQmXfb515vurs_3RFB66DDzmS9kvt8se07JOaVSvKG8LgshZVlQXjBGHmSn-9bDg_okexLCFSG0lpQ_zk7KisqScHaa_di4aArjegvjCNHPuxy6aK5N3OW-z-OAOcYBnLc53sQ5zdb2O9NFGN0Scg1h18E8pdIi9LlxuTWTn7zdBei6AWajsbiVhIg6H6Gb_TTAFsPT7FEPNuCz-_9Z9u3D-68Xn4rLLx8_X2wui05UMhZctq2ue2wIJ1wLUbdMQ8PqCuuG8YYywZCVlRa6TBPNW46s7aumajqg0PTsLHt7pzst7Yi6Q5feYdU0mxHmnfJg1PHEmUFt_bXiVFBZ1Ung9b3A7L8vGKIaTejQWnDol6BKQklZEiblP1FaCSFZxXn9PyilpSRyRV_-gV75ZXbpaLdUI2TD6G9qCxZVstSvfq2ialOxJqmlAybq_C9U-jSOpvMOe5P6RwuvDhYGBBuH4O0SjXfhGCR3YHI4hBn7_YkpUWtc1ZpHteYxVSrFNa28OLRmv_Arn-wnkHXk5A</recordid><startdate>20140903</startdate><enddate>20140903</enddate><creator>Ghosh, Chiranjit</creator><creator>Hong, Bora</creator><creator>Batabyal, Subhasis</creator><creator>Jeon, Tae-Il</creator><creator>Yang, Seung-Hak</creator><creator>Hwang, Seong Gu</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140903</creationdate><title>Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophages</title><author>Ghosh, Chiranjit ; Hong, Bora ; Batabyal, Subhasis ; Jeon, Tae-Il ; Yang, Seung-Hak ; Hwang, Seong Gu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c658t-48bbd7fe90404d667b3da9375e793491363e325d6d2b3dd4b4e3bf5959ca1a9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Animal sciences</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Asia</topic><topic>Cell culture</topic><topic>Cell Line</topic><topic>Chronic illnesses</topic><topic>complement</topic><topic>Cyclooxygenase 2 - genetics</topic><topic>Cyclooxygenase 2 - immunology</topic><topic>Cytokines - immunology</topic><topic>Defense mechanisms</topic><topic>Dictamnus - chemistry</topic><topic>Dictamnus dasycarpus</topic><topic>dose response</topic><topic>Drug therapy</topic><topic>eczema</topic><topic>Environmental science</topic><topic>Enzymes</topic><topic>ethanol</topic><topic>gene expression</topic><topic>immunoblotting</topic><topic>inducible nitric oxide synthase</topic><topic>Inflammation</topic><topic>interleukins</topic><topic>leaves</topic><topic>lipopolysaccharides</topic><topic>Lipopolysaccharides - immunology</topic><topic>macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mice</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - immunology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - immunology</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Nitric Oxide Synthase Type II - immunology</topic><topic>Pathogenesis</topic><topic>Physiological aspects</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>prostaglandin synthase</topic><topic>Protein expression</topic><topic>protein synthesis</topic><topic>Proteins</topic><topic>rheumatoid arthritis</topic><topic>Rodents</topic><topic>Rural development</topic><topic>Studies</topic><topic>transcription factors</topic><topic>tumor necrosis factors</topic><topic>Zoology</topic><toplevel>online_resources</toplevel><creatorcontrib>Ghosh, Chiranjit</creatorcontrib><creatorcontrib>Hong, Bora</creatorcontrib><creatorcontrib>Batabyal, Subhasis</creatorcontrib><creatorcontrib>Jeon, Tae-Il</creatorcontrib><creatorcontrib>Yang, Seung-Hak</creatorcontrib><creatorcontrib>Hwang, Seong Gu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghosh, Chiranjit</au><au>Hong, Bora</au><au>Batabyal, Subhasis</au><au>Jeon, Tae-Il</au><au>Yang, Seung-Hak</au><au>Hwang, Seong Gu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophages</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2014-09-03</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>330</spage><epage>330</epage><pages>330-330</pages><artnum>330</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>Dictamnus dasycarpus is widely used as a traditional remedy for the treatment of eczema, rheumatism, and other inflammatory diseases in Asia. The current study investigates the molecular mechanism of anti-inflammatory action of the ethanol extract of Dictamnus dasycarpus leaf (DE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Nitric oxide (NO) production was assessed by Griess reaction and the mRNA and protein expressions of pro inflammatory cytokines, transcription factor, and enzymes were determined by real-time RT-PCR and immunoblotting analysis.
DE (0.5 and 1 mg/mL) suppressed the NO production by 10 and 33%, respectively, compared to the untreated group in LPS-stimulated RAW 264.7 cells. DE (0.5 and 1 mg/mL) reduced the mRNA expression of key transcription factor nuclear factor-κB by 7 and 24%, respectively compared to the untreated group in LPS activated macrophage. The pro inflammatory cytokines such as tumor necrosis factor α and interleukin 1β were also decreased by DE treatment. Moreover, the protein expression of pro inflammatory enzymes, inducible nitric oxide synthase and cyclooxygenase 2 were also dramatically attenuated by DE in a dose dependent manner.
These results suggest that Dictamnus dasycarpus leaf has a potent anti-inflammatory activity and can be used for the development of new anti-inflammatory agents.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25182043</pmid><doi>10.1186/1472-6882-14-330</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC complementary and alternative medicine, 2014-09, Vol.14 (1), p.330-330, Article 330 |
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| subjects | Analysis Animal sciences Animals anti-inflammatory activity Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Asia Cell culture Cell Line Chronic illnesses complement Cyclooxygenase 2 - genetics Cyclooxygenase 2 - immunology Cytokines - immunology Defense mechanisms Dictamnus - chemistry Dictamnus dasycarpus dose response Drug therapy eczema Environmental science Enzymes ethanol gene expression immunoblotting inducible nitric oxide synthase Inflammation interleukins leaves lipopolysaccharides Lipopolysaccharides - immunology macrophages Macrophages - drug effects Macrophages - immunology Medical research Medicine, Experimental Mice NF-kappa B - genetics NF-kappa B - immunology Nitric oxide Nitric Oxide - immunology Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - immunology Pathogenesis Physiological aspects Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry prostaglandin synthase Protein expression protein synthesis Proteins rheumatoid arthritis Rodents Rural development Studies transcription factors tumor necrosis factors Zoology |
| title | Anti-inflammatory activity of the ethanol extract of Dictamnus dasycarpus leaf in lipopolysaccharide-activated macrophages |
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