An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus)
The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The animal model for MS established i...
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| Veröffentlicht in: | Experimental Animals 2013, Vol.62(3), pp.159-171 |
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| creator | Jagessar, S. Anwar Vierboom, Michel Blezer, Erwin L.A. Bauer, Jan Hart, Bert A. ‘t Kap, Yolanda S. |
| description | The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The animal model for MS established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificity for humans. Effective usage of the marmoset in preclinical immunological research has been hampered by the limited availability of blood for immunological studies and of reagents for profiling of cellular and humoral immune reactions. In this paper, we give a concise overview of the procedures and reagents that were developed over the years in our laboratory in marmoset models of the above-mentioned diseases. |
| doi_str_mv | 10.1538/expanim.62.159 |
| format | Article |
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Anwar ; Vierboom, Michel ; Blezer, Erwin L.A. ; Bauer, Jan ; Hart, Bert A. ‘t ; Kap, Yolanda S.</creator><creatorcontrib>Jagessar, S. Anwar ; Vierboom, Michel ; Blezer, Erwin L.A. ; Bauer, Jan ; Hart, Bert A. ‘t ; Kap, Yolanda S.</creatorcontrib><description>The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The animal model for MS established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificity for humans. Effective usage of the marmoset in preclinical immunological research has been hampered by the limited availability of blood for immunological studies and of reagents for profiling of cellular and humoral immune reactions. 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Anwar</creatorcontrib><creatorcontrib>Vierboom, Michel</creatorcontrib><creatorcontrib>Blezer, Erwin L.A.</creatorcontrib><creatorcontrib>Bauer, Jan</creatorcontrib><creatorcontrib>Hart, Bert A. ‘t</creatorcontrib><creatorcontrib>Kap, Yolanda S.</creatorcontrib><title>An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus)</title><title>Experimental Animals</title><addtitle>Exp Anim</addtitle><description>The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The animal model for MS established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificity for humans. Effective usage of the marmoset in preclinical immunological research has been hampered by the limited availability of blood for immunological studies and of reagents for profiling of cellular and humoral immune reactions. In this paper, we give a concise overview of the procedures and reagents that were developed over the years in our laboratory in marmoset models of the above-mentioned diseases.</description><subject>Animals</subject><subject>Animals, Laboratory</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoimmunity</subject><subject>Callithrix</subject><subject>Cross-Linking Reagents</subject><subject>Disease Models, Animal</subject><subject>Encephalomyelitis - immunology</subject><subject>experimental autoimmune encephalomyelitis</subject><subject>Female</subject><subject>Humans</subject><subject>immunology</subject><subject>Male</subject><subject>multiple sclerosis</subject><subject>Multiple Sclerosis - immunology</subject><subject>nonhuman primate</subject><subject>Review</subject><subject>rheumatoid arthritis</subject><subject>Translational Medical Research - methods</subject><issn>1341-1357</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1rGzEQhpfS0KRprz0WHVvIOvrwfl0Kxk0_ICYQfBez0igro5WMJLvJX-ivziZOTXqaGeadZ5h5i-ITozNWifYS77fg7Tir-VR3b4oz1rasbBjnb6dczFnJRNWcFu9T2lDKm4Z374pTLjoqaEXPir8LT272GPcW_5BgyCpodOmCrDAPQU8JeE1uEe7Q50S-4x5d2KImJkSyjuCTg2yDB0cWuxzsOO68zQ_TREKIaiDWkzwgWYZxDJ6sII4hYSZfluCczUO092QDSg279PVDcWLAJfz4Es-L9Y-r9fJXeX3z8_dycV2qqhO5RGFAcaNNp9tGG6E5BVpjJajAivVdo_oaqGhML7Rh2nAmTN9gx3shdN-J8-LbAbvd9SNqNR0WwclttCPEBxnAyv873g7yLuzlnNW0m7MJMDsAVAwpRTTHWUblkynyxRRZ86l-2vj59caj_J8Lk-DqINikPH36KICYrXL4mieeoVxSWrXHvhogSvTiEdCHp7g</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Jagessar, S. Anwar</creator><creator>Vierboom, Michel</creator><creator>Blezer, Erwin L.A.</creator><creator>Bauer, Jan</creator><creator>Hart, Bert A. ‘t</creator><creator>Kap, Yolanda S.</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>2013</creationdate><title>An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus)</title><author>Jagessar, S. Anwar ; Vierboom, Michel ; Blezer, Erwin L.A. ; Bauer, Jan ; Hart, Bert A. ‘t ; Kap, Yolanda S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-e3fac2fdf9d87df3d20a06e5303e51b97cb6a037fb3df1df213fb7e92b33db93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Animals, Laboratory</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoimmunity</topic><topic>Callithrix</topic><topic>Cross-Linking Reagents</topic><topic>Disease Models, Animal</topic><topic>Encephalomyelitis - immunology</topic><topic>experimental autoimmune encephalomyelitis</topic><topic>Female</topic><topic>Humans</topic><topic>immunology</topic><topic>Male</topic><topic>multiple sclerosis</topic><topic>Multiple Sclerosis - immunology</topic><topic>nonhuman primate</topic><topic>Review</topic><topic>rheumatoid arthritis</topic><topic>Translational Medical Research - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jagessar, S. Anwar</creatorcontrib><creatorcontrib>Vierboom, Michel</creatorcontrib><creatorcontrib>Blezer, Erwin L.A.</creatorcontrib><creatorcontrib>Bauer, Jan</creatorcontrib><creatorcontrib>Hart, Bert A. ‘t</creatorcontrib><creatorcontrib>Kap, Yolanda S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jagessar, S. 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The animal model for MS established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificity for humans. Effective usage of the marmoset in preclinical immunological research has been hampered by the limited availability of blood for immunological studies and of reagents for profiling of cellular and humoral immune reactions. In this paper, we give a concise overview of the procedures and reagents that were developed over the years in our laboratory in marmoset models of the above-mentioned diseases.</abstract><cop>Japan</cop><pub>Japanese Association for Laboratory Animal Science</pub><pmid>23903050</pmid><doi>10.1538/expanim.62.159</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Animals, Laboratory Arthritis, Rheumatoid - immunology Autoimmunity Callithrix Cross-Linking Reagents Disease Models, Animal Encephalomyelitis - immunology experimental autoimmune encephalomyelitis Female Humans immunology Male multiple sclerosis Multiple Sclerosis - immunology nonhuman primate Review rheumatoid arthritis Translational Medical Research - methods |
| title | An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus) |
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