microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis

microRNAs (miRNA) are essential for regulatory T cell (Treg) function but little is known about the functional relevance of individual miRNA loci. We identified the miR-17-92 cluster as CD28 costimulation dependent, suggesting that it may be key for Treg development and function. Although overall im...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2013-08, Vol.191 (4), p.1594-1605
Hauptverfasser:	de Kouchkovsky, Dimitri, Esensten, Jonathan H, Rosenthal, Wendy L, Morar, Malika M, Bluestone, Jeffrey A, Jeker, Lukas T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antigen Presentation Apoptosis Regulatory Proteins - genetics Bcl-2-Like Protein 11 CD28 Antigens - immunology Cells, Cultured Costimulatory and Inhibitory T-Cell Receptors - immunology Encephalomyelitis, Autoimmune, Experimental - immunology Epitopes, T-Lymphocyte - immunology Gene Deletion Heterozygote Histocompatibility Antigens Class II - immunology Homeostasis Humans Interleukin-10 - biosynthesis Lymphocyte Activation Male Membrane Proteins - genetics Mice Mice, Knockout MicroRNAs - genetics MicroRNAs - immunology Myelin-Oligodendrocyte Glycoprotein - immunology Peptide Fragments - immunology Proto-Oncogene Proteins - genetics PTEN Phosphohydrolase - deficiency T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!