High Guanidinium Permeability Reveals Dehydration-Dependent Ion Selectivity in the Plasmodial Surface Anion Channel

Malaria parasites grow within vertebrate erythrocytes and increase host cell permeability to access nutrients from plasma. This increase is mediated by the plasmodial surface anion channel (PSAC), an unusual ion channel linked to the conserved clag gene family. Although PSAC recognizes and transport...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-8
Hauptverfasser:	Pillai, Ajay D., Fuller, Alexandra, Mita-Mendoza, Neida K., Bokhari, Abdullah A. B., Desai, Sanjay A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood banks Cell Membrane Permeability - physiology Dehydration Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - metabolism Erythrocytes - parasitology Guanidine Guanidine - chemistry Guanidine - metabolism Health aspects Humans Ion channels Ion Channels - chemistry Ion Channels - metabolism Malaria Malaria, Falciparum - metabolism Malaria, Falciparum - parasitology Parasites Permeability Plasmodium falciparum Studies Temperature
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