The FEN1 E359K germline mutation disrupts the FEN1–WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers

Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair, can lead to functional deficiencies of the FEN1 protein and a predisposition to cancer. We identified a FEN1 germline mutation that changed residue E359 to K in a patient wh...

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Veröffentlicht in:	Oncogene 2015-02, Vol.34 (7), p.902-911
Hauptverfasser:	Chung, L, Onyango, D, Guo, Z, Jia, P, Dai, H, Liu, S, Zhou, M, Lin, W, Pang, I, Li, H, Yuan, Y-C, Huang, Q, Zheng, L, Lopes, J, Nicolas, A, Chai, W, Raz, D, Reckamp, K L, Shen, B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 631/67/1347 631/67/68 Amino Acid Substitution Aneuploidy Animals Apoptosis Breast cancer Cancer Causes of Cell Biology Cell Line Complications and side effects Deoxyribonucleic acid Development and progression DNA DNA biosynthesis DNA repair DNA Replication - genetics DNA, Neoplasm - biosynthesis DNA, Neoplasm - genetics Embryo fibroblasts Embryo, Mammalian - metabolism Embryo, Mammalian - pathology Embryos Endonuclease Enzymes Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Female FEN1 protein Fibroblasts - metabolism Fibroblasts - pathology Flap Endonucleases - genetics Flap Endonucleases - metabolism Gene mutations Genetic aspects Health aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mice Mice, Mutant Strains Mutants Mutation Mutation, Missense Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oncology original-article Polymorphism Proteins RecQ Helicases - genetics RecQ Helicases - metabolism Replication forks Telomeres Werner Syndrome Helicase Werner's syndrome
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