Anabolic exercise in haemodialysis patients: a randomised controlled pilot study
Background The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialy...
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| Veröffentlicht in: | Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2014-09, Vol.5 (3), p.199-207 |
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| container_title | Journal of cachexia, sarcopenia and muscle |
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| creator | Kirkman, Danielle L. Mullins, Paul Junglee, Naushad A. Kumwenda, Mick Jibani, Mahdi M. Macdonald, Jamie H. |
| description | Background
The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program.
Methods
In a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high-intensity exercise leg extensions using novel equipment. SHAM completed low-intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12 weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between-group comparisons.
Results
PRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET—SHAM, mean difference [95 % CI]: 193[63 to 324] cm
3
) that was very similar to the response in healthy participants (PRET—SHAM, 169[−41 to 379] cm
3
). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants.
Conclusions
Intradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation. |
| doi_str_mv | 10.1007/s13539-014-0140-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4159488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2299177801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c7619-71b26cf68aa334ab574e0ec8a08e31a0c0b0e23b3fc79dcacd678fc9e5efec433</originalsourceid><addsrcrecordid>eNqFUdFqFTEUDKLY0vYDfJEFX3xZPdlkk42IUC5qLRUF9Tlks2fblNzkmuxa7983l722KoiBQw5kZpjJEPKEwgsKIF9mylqmaqB8N1CzB-SwoQpqAaAe7vdWKXpATnK-hnK4oKKFx-Sg4ZKCUPKQfD4Npo_e2Qp_YrIuY-VCdWVwHQdn_Da7XG3M5DBM-VVlqmTCENcFNlQ2hilF78u6cT5OVZ7mYXtMHo3GZzzZ30fk27u3X1dn9cWn9x9Wpxe1lYKqWtK-EXYUnTGMcdO3kiOg7Qx0yKgBCz1gw3o2WqkGa-wgZDdahS2OaDljR-TNoruZ-zUOthhMxutNcmuTtjoap_98Ce5KX8YfmtNW8a4rAs_3Ail-nzFPusSy6L0JGOesaSsoFwoEL9Bnf0Gv45xCiaebpvywlB3QgqILyqaYc8LxzgwFvatML5XpUtduQO9SPP09xR3jV0EF8HoB3DiP2_8r6vPVl49N2VtGlSr0ZqHnwgyXmO6d_9vULTFStHI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2299177801</pqid></control><display><type>article</type><title>Anabolic exercise in haemodialysis patients: a randomised controlled pilot study</title><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Kirkman, Danielle L. ; Mullins, Paul ; Junglee, Naushad A. ; Kumwenda, Mick ; Jibani, Mahdi M. ; Macdonald, Jamie H.</creator><creatorcontrib>Kirkman, Danielle L. ; Mullins, Paul ; Junglee, Naushad A. ; Kumwenda, Mick ; Jibani, Mahdi M. ; Macdonald, Jamie H.</creatorcontrib><description>Background
The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program.
Methods
In a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high-intensity exercise leg extensions using novel equipment. SHAM completed low-intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12 weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between-group comparisons.
Results
PRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET—SHAM, mean difference [95 % CI]: 193[63 to 324] cm
3
) that was very similar to the response in healthy participants (PRET—SHAM, 169[−41 to 379] cm
3
). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants.
Conclusions
Intradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation.</description><identifier>ISSN: 2190-5991</identifier><identifier>EISSN: 2190-6009</identifier><identifier>DOI: 10.1007/s13539-014-0140-3</identifier><identifier>PMID: 24710697</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atrophy ; Authorship ; Body composition ; Chronic kidney failure ; Clinical Nutrition ; Fitness training programs ; Geriatrics/Gerontology ; Haemodialysis ; Health services ; Hemodialysis ; Internal Medicine ; Intervention ; Kidney diseases ; Medicine ; Medicine & Public Health ; Molecular Medicine ; Mortality ; Oncology ; Original ; Original Article ; Patients ; Pharmacology/Toxicology ; Protein synthesis ; Proteins ; Quality of life ; Wasting syndrome ; Weight lifting</subject><ispartof>Journal of cachexia, sarcopenia and muscle, 2014-09, Vol.5 (3), p.199-207</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>2014 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders</rights><rights>2014. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c7619-71b26cf68aa334ab574e0ec8a08e31a0c0b0e23b3fc79dcacd678fc9e5efec433</citedby><cites>FETCH-LOGICAL-c7619-71b26cf68aa334ab574e0ec8a08e31a0c0b0e23b3fc79dcacd678fc9e5efec433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159488/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159488/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24710697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirkman, Danielle L.</creatorcontrib><creatorcontrib>Mullins, Paul</creatorcontrib><creatorcontrib>Junglee, Naushad A.</creatorcontrib><creatorcontrib>Kumwenda, Mick</creatorcontrib><creatorcontrib>Jibani, Mahdi M.</creatorcontrib><creatorcontrib>Macdonald, Jamie H.</creatorcontrib><title>Anabolic exercise in haemodialysis patients: a randomised controlled pilot study</title><title>Journal of cachexia, sarcopenia and muscle</title><addtitle>J Cachexia Sarcopenia Muscle</addtitle><addtitle>J Cachexia Sarcopenia Muscle</addtitle><description>Background
The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program.
Methods
In a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high-intensity exercise leg extensions using novel equipment. SHAM completed low-intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12 weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between-group comparisons.
Results
PRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET—SHAM, mean difference [95 % CI]: 193[63 to 324] cm
3
) that was very similar to the response in healthy participants (PRET—SHAM, 169[−41 to 379] cm
3
). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants.
Conclusions
Intradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation.</description><subject>Atrophy</subject><subject>Authorship</subject><subject>Body composition</subject><subject>Chronic kidney failure</subject><subject>Clinical Nutrition</subject><subject>Fitness training programs</subject><subject>Geriatrics/Gerontology</subject><subject>Haemodialysis</subject><subject>Health services</subject><subject>Hemodialysis</subject><subject>Internal Medicine</subject><subject>Intervention</subject><subject>Kidney diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular Medicine</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pharmacology/Toxicology</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Quality of life</subject><subject>Wasting syndrome</subject><subject>Weight lifting</subject><issn>2190-5991</issn><issn>2190-6009</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNqFUdFqFTEUDKLY0vYDfJEFX3xZPdlkk42IUC5qLRUF9Tlks2fblNzkmuxa7983l722KoiBQw5kZpjJEPKEwgsKIF9mylqmaqB8N1CzB-SwoQpqAaAe7vdWKXpATnK-hnK4oKKFx-Sg4ZKCUPKQfD4Npo_e2Qp_YrIuY-VCdWVwHQdn_Da7XG3M5DBM-VVlqmTCENcFNlQ2hilF78u6cT5OVZ7mYXtMHo3GZzzZ30fk27u3X1dn9cWn9x9Wpxe1lYKqWtK-EXYUnTGMcdO3kiOg7Qx0yKgBCz1gw3o2WqkGa-wgZDdahS2OaDljR-TNoruZ-zUOthhMxutNcmuTtjoap_98Ce5KX8YfmtNW8a4rAs_3Ail-nzFPusSy6L0JGOesaSsoFwoEL9Bnf0Gv45xCiaebpvywlB3QgqILyqaYc8LxzgwFvatML5XpUtduQO9SPP09xR3jV0EF8HoB3DiP2_8r6vPVl49N2VtGlSr0ZqHnwgyXmO6d_9vULTFStHI</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Kirkman, Danielle L.</creator><creator>Mullins, Paul</creator><creator>Junglee, Naushad A.</creator><creator>Kumwenda, Mick</creator><creator>Jibani, Mahdi M.</creator><creator>Macdonald, Jamie H.</creator><general>Springer Berlin Heidelberg</general><general>Springer‐Verlag</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201409</creationdate><title>Anabolic exercise in haemodialysis patients: a randomised controlled pilot study</title><author>Kirkman, Danielle L. ; Mullins, Paul ; Junglee, Naushad A. ; Kumwenda, Mick ; Jibani, Mahdi M. ; Macdonald, Jamie H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c7619-71b26cf68aa334ab574e0ec8a08e31a0c0b0e23b3fc79dcacd678fc9e5efec433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Atrophy</topic><topic>Authorship</topic><topic>Body composition</topic><topic>Chronic kidney failure</topic><topic>Clinical Nutrition</topic><topic>Fitness training programs</topic><topic>Geriatrics/Gerontology</topic><topic>Haemodialysis</topic><topic>Health services</topic><topic>Hemodialysis</topic><topic>Internal Medicine</topic><topic>Intervention</topic><topic>Kidney diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Molecular Medicine</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pharmacology/Toxicology</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Quality of life</topic><topic>Wasting syndrome</topic><topic>Weight lifting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirkman, Danielle L.</creatorcontrib><creatorcontrib>Mullins, Paul</creatorcontrib><creatorcontrib>Junglee, Naushad A.</creatorcontrib><creatorcontrib>Kumwenda, Mick</creatorcontrib><creatorcontrib>Jibani, Mahdi M.</creatorcontrib><creatorcontrib>Macdonald, Jamie H.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cachexia, sarcopenia and muscle</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirkman, Danielle L.</au><au>Mullins, Paul</au><au>Junglee, Naushad A.</au><au>Kumwenda, Mick</au><au>Jibani, Mahdi M.</au><au>Macdonald, Jamie H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anabolic exercise in haemodialysis patients: a randomised controlled pilot study</atitle><jtitle>Journal of cachexia, sarcopenia and muscle</jtitle><stitle>J Cachexia Sarcopenia Muscle</stitle><addtitle>J Cachexia Sarcopenia Muscle</addtitle><date>2014-09</date><risdate>2014</risdate><volume>5</volume><issue>3</issue><spage>199</spage><epage>207</epage><pages>199-207</pages><issn>2190-5991</issn><eissn>2190-6009</eissn><abstract>Background
The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program.
Methods
In a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high-intensity exercise leg extensions using novel equipment. SHAM completed low-intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12 weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between-group comparisons.
Results
PRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET—SHAM, mean difference [95 % CI]: 193[63 to 324] cm
3
) that was very similar to the response in healthy participants (PRET—SHAM, 169[−41 to 379] cm
3
). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants.
Conclusions
Intradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24710697</pmid><doi>10.1007/s13539-014-0140-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Atrophy Authorship Body composition Chronic kidney failure Clinical Nutrition Fitness training programs Geriatrics/Gerontology Haemodialysis Health services Hemodialysis Internal Medicine Intervention Kidney diseases Medicine Medicine & Public Health Molecular Medicine Mortality Oncology Original Original Article Patients Pharmacology/Toxicology Protein synthesis Proteins Quality of life Wasting syndrome Weight lifting |
| title | Anabolic exercise in haemodialysis patients: a randomised controlled pilot study |
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