Key role of regulated upon activation normal T-cell expressed and secreted, nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells

ABSTRACT Influenza virus infection causes severe respiratory disease such as that due to avian influenza (H5N1). Influenza A viruses proliferate in human epithelial cells, which produce inflammatory cytokines/chemokines as a “cytokine storm” attenuated with the viral nonstructural protein 1 (NS1). C...

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Veröffentlicht in:	Microbiology and immunology 2011-12, Vol.55 (12), p.874-884
Hauptverfasser:	Phung, Thuy Thi Bich, Sugamata, Ryuichi, Uno, Kazuko, Aratani, Yasuaki, Ozato, Keiko, Kawachi, Shoji, Thanh Nguyen, Liem, Nakayama, Toshinori, Suzuki, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	bronchial epithelial cells Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Chemokine CCL5 - administration & dosage Chemokine CCL5 - genetics Chemokine CCL5 - metabolism Chemokines - drug effects Chemokines - genetics Chemokines - physiology Cytokines - drug effects Cytokines - genetics Cytokines - physiology Down-Regulation Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - virology Gene Expression Regulation Gene Knockdown Techniques Humans Hydrogen Peroxide - pharmacology Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - physiology influenza viral NS1 Influenza, Human - immunology Influenza, Human - virology Lymphocyte Activation myloperoxidase Neutrophils - enzymology Neutrophils - immunology Neutrophils - virology Peroxidase - administration & dosage Peroxidase - metabolism Recombinant Proteins regulated upon activation normal T-cell expressed and secreted RNA, Small Interfering Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - genetics Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism
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