Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

•AMPK is activated by oxidative stress generated using glucose oxidase.•Activation is largely, but not solely, mediated by increases in AMP and/or ADP.•Increases in Thr172 phosphorylation are mediated by inhibition of dephosphorylation. AMPK is known to be activated by oxidative stress. Addition of...

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Veröffentlicht in:	FEBS letters 2014-09, Vol.588 (18), p.3361-3366
Hauptverfasser:	Auciello, F. Romana, Ross, Fiona A., Ikematsu, Naoko, Hardie, D. Grahame
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Monophosphate - metabolism ADP AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism AMPK calmodulin-dependent kinase kinase CaMKK Enzyme Activation glucose oxidase HEK293 Cells HeLa Cells Humans Hydrogen peroxide Hydrogen Peroxide - metabolism liver kinase B1 LKB1 Oxidative Stress Protein Processing, Post-Translational
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