The mechanism of degeneration of striatal neuronal subtypes in Huntington disease

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease

The pattern of neurodegeneration in Huntington's disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In...

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Veröffentlicht in:Annals of Neurosciences 2014-07, Vol.21 (3), p.112-114
Hauptverfasser: Rikani, Azadeh A, Choudhry, Zia, Choudhry, Adnan M, Rizvi, Nasir, Ikram, Huma, Mobassarah, Nusrat J, Tulli, Sagun
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container_issue 3
container_start_page 112
container_title Annals of Neurosciences
container_volume 21
creator Rikani, Azadeh A
Choudhry, Zia
Choudhry, Adnan M
Rizvi, Nasir
Ikram, Huma
Mobassarah, Nusrat J
Tulli, Sagun
description The pattern of neurodegeneration in Huntington's disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD. In an attempt to explain a likely mechanism of degeneration of striatal neuronal populations in HD, possible causes underlying differential vulnerability of neuronal subtypes to excitoxic insults and neurotrophic factors are discussed in this paper.
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title The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
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