Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts

The LIM homeobox 2 (Lhx2) transcription factor Lhx2 has a variety of functions, including neural induction, morphogenesis, and hematopoiesis. Here we show the involvement of Lhx2 in osteoclast differentiation. Lhx2 was strongly expressed in osteoclast precursor cells but its expression was significa...

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Veröffentlicht in:	Cell death and differentiation 2014-10, Vol.21 (10), p.1613-1621
Hauptverfasser:	Kim, J H, Youn, B U, Kim, K, Moon, J B, Lee, J, Nam, K-I I, Park, Y-W, O'Leary, D D M, Kim, K K, Kim, N
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 631/337 631/80 64/60 96/95 Animals Apoptosis Biochemistry Biomedical and Life Sciences Bone marrow Bone Marrow Cells - metabolism Bone Remodeling - genetics Cell Biology Cell Cycle Analysis Cell death Cell Differentiation - genetics Cells, Cultured DNA-Binding Proteins Down-Regulation Gene Expression Regulation Kinases Life Sciences Ligands LIM-Homeodomain Proteins - biosynthesis LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Lymphocytes Macrophages - metabolism Medical schools Mice Mice, Knockout Neurosciences NFATC Transcription Factors - antagonists & inhibitors Original Paper Osteoclasts - cytology Osteogenesis - genetics Osteoporosis - genetics Phosphatase Proteins Proto-Oncogene Proteins c-fos - metabolism RANK Ligand - metabolism RNA Interference RNA, Small Interfering Signal Transduction Stem Cells Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - metabolism Tumor necrosis factor-TNF
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