locus on chromosome 9 is associated with differential response of 129S1/SvImJ and FVB/NJ strains of mice to systemic LPS

Although polymorphisms in TLR receptors and downstream signaling molecules affect the innate immune response, these variants account for only a portion of the ability of the host to respond to microorganisms. To identify novel genes that regulate the host response to systemic lipopolysaccharide (LPS...

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Veröffentlicht in:	Mammalian genome 2011-10, Vol.22 (9-10), p.518-529
Hauptverfasser:	Yang, Ivana V, Rutledge, Holly R, Yang, Jun, Warg, Laura A, Sevilla, Sergio D, Schwartz, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Biomedical and Life Sciences blood blood serum caspases Caspases - genetics Caspases, Initiator Cell Biology Chromosome Mapping Chromosomes, Mammalian Cytokines Cytokines - blood Cytokines - immunology Disease Models, Animal Escherichia coli Infections Escherichia coli Infections - genetics Escherichia coli Infections - immunology Escherichia coli Infections - mortality Female genes Genetic Loci Genetic Predisposition to Disease genetics Human Genetics immunology innate immunity interleukin-1beta interleukin-6 intraperitoneal injection Kaplan-Meier Estimate Life Sciences lipopolysaccharides Lipopolysaccharides - immunology loci Male Mice Mice, 129 Strain Mice, Inbred Strains microorganisms morbidity mortality Phenotype Polymorphism, Single Nucleotide progeny receptors reverse transcriptase polymerase chain reaction Shock, Septic Shock, Septic - genetics Shock, Septic - immunology Shock, Septic - mortality telomeres
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