Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults
Abstract The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2014-10, Vol.91 (4), p.161-168 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Flock, Michael R Skulas-Ray, Ann C Harris, William S Gaugler, Trent L Fleming, Jennifer A Kris-Etherton, Penny M |
| description | Abstract The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake ( n =116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α ( p |
| doi_str_mv | 10.1016/j.plefa.2014.07.006 |
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We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake ( n =116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α ( p <0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α ( p =0.001); higher quartiles of arachidonic acid were associated with higher TNF-α ( p =0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2014.07.006</identifier><identifier>PMID: 25091379</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Advanced Basic Science ; C-reactive protein (CRP) ; C-Reactive Protein - metabolism ; Dietary Supplements ; Docosahexaenoic acid (DHA) ; Docosahexaenoic Acids - therapeutic use ; Docosapentaenoic acid (DPA) ; Eicosapentaenoic acid (EPA) ; Eicosapentaenoic Acid - therapeutic use ; Endocrinology & Metabolism ; Erythrocyte Membrane - metabolism ; Fatty Acids - metabolism ; Fatty Acids, Omega-3 - therapeutic use ; Humans ; Inflammation ; Interleukin-6 - blood ; Middle Aged ; Omega-3 ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2014-10, Vol.91 (4), p.161-168</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>2014 Elsevier Ltd. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c654t-23460c4e380ee8a0af2bb7ea71a6f891aca3057ecbd94ba6635ceacd0ce48ca83</citedby><cites>FETCH-LOGICAL-c654t-23460c4e380ee8a0af2bb7ea71a6f891aca3057ecbd94ba6635ceacd0ce48ca83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.plefa.2014.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25091379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flock, Michael R</creatorcontrib><creatorcontrib>Skulas-Ray, Ann C</creatorcontrib><creatorcontrib>Harris, William S</creatorcontrib><creatorcontrib>Gaugler, Trent L</creatorcontrib><creatorcontrib>Fleming, Jennifer A</creatorcontrib><creatorcontrib>Kris-Etherton, Penny M</creatorcontrib><title>Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Abstract The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake ( n =116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α ( p <0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α ( p =0.001); higher quartiles of arachidonic acid were associated with higher TNF-α ( p =0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.</description><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>C-reactive protein (CRP)</subject><subject>C-Reactive Protein - metabolism</subject><subject>Dietary Supplements</subject><subject>Docosahexaenoic acid (DHA)</subject><subject>Docosahexaenoic Acids - therapeutic use</subject><subject>Docosapentaenoic acid (DPA)</subject><subject>Eicosapentaenoic acid (EPA)</subject><subject>Eicosapentaenoic Acid - therapeutic use</subject><subject>Endocrinology & Metabolism</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-6 - blood</subject><subject>Middle Aged</subject><subject>Omega-3</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstuFDEQHCEQWQJfgIR85DJL257XHoiEovCQInEAzlaPp2fXG4-92J5Iw5_xd3jZEAUunGy5q6rLXV0ULzmsOfDmzX59sDTiWgCv1tCuAZpHxYrXUpSiE_JxsYJNLUop2u6seBbjHgAE59XT4kzUsOGy3ayKn1fjSDpF5kcW50NWnMgltMx6ty31Do1jfqItlpKNmNLCUJshMnQDo7CkXfB6ScQmmvqAjh6AmPYuZTHmHdMm6NliMm7LjBstThMmHxY2YbihEPMjQ5YFBj-ZH3TiBm9tvqZgsp_sb0do0y6LD7NN8XnxZEQb6cXdeV58e3_19fJjef35w6fLd9elbuoqlUJWDeiKZAdEHQKOou9bwpZjM3Ybjhol1C3pfthUPTaNrDWhHkBT1Wns5HlxcdI9zP1Eg84_CmjVIZjsfVEejfq74sxObf2tqnjdbEBkgdd3AsF_nykmNZmoydo8Lj9HlWFQd9ByyFB5gurgYww03rfhoI6hq736Hbo6hq6gVTn0zHr10OE950_KGfD2BKA8p1tDQUVtyGkaTMjhq8Gb_zS4-IevrXFGo72hheLez8HlCBRXUShQX457d1w7XgFwqGr5C2y72vE</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Flock, Michael R</creator><creator>Skulas-Ray, Ann C</creator><creator>Harris, William S</creator><creator>Gaugler, Trent L</creator><creator>Fleming, Jennifer A</creator><creator>Kris-Etherton, Penny M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults</title><author>Flock, Michael R ; Skulas-Ray, Ann C ; Harris, William S ; Gaugler, Trent L ; Fleming, Jennifer A ; Kris-Etherton, Penny M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c654t-23460c4e380ee8a0af2bb7ea71a6f891aca3057ecbd94ba6635ceacd0ce48ca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>C-reactive protein (CRP)</topic><topic>C-Reactive Protein - metabolism</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic acid (DHA)</topic><topic>Docosahexaenoic Acids - therapeutic use</topic><topic>Docosapentaenoic acid (DPA)</topic><topic>Eicosapentaenoic acid (EPA)</topic><topic>Eicosapentaenoic Acid - therapeutic use</topic><topic>Endocrinology & Metabolism</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Fatty Acids - metabolism</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-6 - blood</topic><topic>Middle Aged</topic><topic>Omega-3</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flock, Michael R</creatorcontrib><creatorcontrib>Skulas-Ray, Ann C</creatorcontrib><creatorcontrib>Harris, William S</creatorcontrib><creatorcontrib>Gaugler, Trent L</creatorcontrib><creatorcontrib>Fleming, Jennifer A</creatorcontrib><creatorcontrib>Kris-Etherton, Penny M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flock, Michael R</au><au>Skulas-Ray, Ann C</au><au>Harris, William S</au><au>Gaugler, Trent L</au><au>Fleming, Jennifer A</au><au>Kris-Etherton, Penny M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>91</volume><issue>4</issue><spage>161</spage><epage>168</epage><pages>161-168</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake ( n =116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α ( p <0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α ( p =0.001); higher quartiles of arachidonic acid were associated with higher TNF-α ( p =0.005). 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| subjects | Adult Advanced Basic Science C-reactive protein (CRP) C-Reactive Protein - metabolism Dietary Supplements Docosahexaenoic acid (DHA) Docosahexaenoic Acids - therapeutic use Docosapentaenoic acid (DPA) Eicosapentaenoic acid (EPA) Eicosapentaenoic Acid - therapeutic use Endocrinology & Metabolism Erythrocyte Membrane - metabolism Fatty Acids - metabolism Fatty Acids, Omega-3 - therapeutic use Humans Inflammation Interleukin-6 - blood Middle Aged Omega-3 Tumor Necrosis Factor-alpha - blood |
| title | Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults |
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