Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin

Fibrosarcomas show a high incidence of recurrence and general resistance to apoptosis. Limiting tumor regrowth and increasing their sensitivity to chemotherapy and apoptosis represent key issues in developing more effective treatments of these tumors. Tissue inhibitor of metalloproteinase 1 (TIMP-1)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Targeted oncology 2014-09, Vol.9 (3), p.251-261
Hauptverfasser:	Bao, Q., Niess, H., Djafarzadeh, R., Zhao, Y., Schwarz, B., Angele, M. K., Jauch, K.-W., Nelson, P. J., Bruns, C. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Biological and medical sciences Biomedicine Cell Line, Tumor Cell Proliferation - drug effects Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Synergism Female Fibrosarcoma - drug therapy Fibrosarcoma - pathology Glycosylphosphatidylinositols - administration & dosage Glycosylphosphatidylinositols - pharmacology Humans Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Original Research Random Allocation Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - pharmacology Tissue Inhibitor of Metalloproteinase-1 - administration & dosage Tissue Inhibitor of Metalloproteinase-1 - pharmacology Tumors Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!