Prolactin (PRL)-stimulated Ubiquitination of ZnT2 Mediates a Transient Increase in Zinc Secretion Followed by ZnT2 Degradation in Mammary Epithelial Cells

The zinc transporter ZnT2 imports zinc into secretory vesicles and regulates zinc export from the mammary epithelial cell. Mutations in ZnT2 substantially impair zinc secretion into milk. The lactogenic hormone prolactin (PRL) transcriptionally increases ZnT2 expression through the Jak2/STAT5 signal...

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Veröffentlicht in:	The Journal of biological chemistry 2014-08, Vol.289 (34), p.23653-23661
Hauptverfasser:	Seo, Young Ah, Lee, Sooyeon, Hennigar, Stephen R., Kelleher, Shannon L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cation Transport Proteins - physiology Cell Line Epithelial Cells - metabolism Female Immunoprecipitation Lysine - metabolism Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Membrane Biology Mice Prolactin - physiology Protein Processing, Post-Translational RNA, Small Interfering Ubiquitination - physiology
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