Reversibility of retinal microvascular changes in severe falciparum malaria

Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular...

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Veröffentlicht in:The American journal of tropical medicine and hygiene 2014-09, Vol.91 (3), p.493-495
Hauptverfasser: Maude, Richard J, Kingston, Hugh W F, Joshi, Sonia, Mohanty, Sanjib, Mishra, Saroj K, White, Nicholas J, Dondorp, Arjen M
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Sprache:eng
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Zusammenfassung:Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.14-0116