Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites

Controlled human malaria infection (CHMI) by mosquito bite has been used to assess anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes by feeding on Plasmodium falciparum (Pf) gametocyte cultures. Such CHMIs have never been used in Africa. Asepti...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2014-09, Vol.91 (3), p.471-480
Hauptverfasser:	Shekalaghe, Seif, Rutaihwa, Mastidia, Billingsley, Peter F, Chemba, Mwajuma, Daubenberger, Claudia A, James, Eric R, Mpina, Maximillian, Ali Juma, Omar, Schindler, Tobias, Huber, Eric, Gunasekera, Anusha, Manoj, Anita, Simon, Beatus, Saverino, Elizabeth, Church, L W Preston, Hermsen, Cornelus C, Sauerwein, Robert W, Plowe, Christopher, Venkatesan, Meera, Sasi, Philip, Lweno, Omar, Mutani, Paul, Hamad, Ali, Mohammed, Ali, Urassa, Alwisa, Mzee, Tutu, Padilla, Debbie, Ruben, Adam, Sim, B Kim Lee, Tanner, Marcel, Abdulla, Salim, Hoffman, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Thalassemia - genetics Animals Cryopreservation Double-Blind Method Genotype Humans Injections, Intradermal Malaria Vaccines - administration & dosage Malaria Vaccines - adverse effects Malaria, Falciparum - parasitology Malaria, Falciparum - prevention & control Male Parasitemia Plasmodium falciparum Plasmodium falciparum - classification Plasmodium falciparum - genetics Plasmodium falciparum - immunology Sporozoites - immunology Tanzania Young Adult
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