Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy
AIM: To investigate the relationship between low immediate postoperative platelet count and perioperative outcome after liver resection in patients with hepatocellular carcinoma(HCC).METHODS: In a cohort of 565 consecutive hepatitis B-related HCC patients who underwent major liver resection, the cha...
Gespeichert in:
| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-09, Vol.20 (33), p.11871-11877 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11877 |
|---|---|
| container_issue | 33 |
| container_start_page | 11871 |
| container_title | World journal of gastroenterology : WJG |
| container_volume | 20 |
| creator | Wang, Hai-Qing Yang, Jian Yang, Jia-Yin Wang, Wen-Tao Yan, Lu-Nan |
| description | AIM: To investigate the relationship between low immediate postoperative platelet count and perioperative outcome after liver resection in patients with hepatocellular carcinoma(HCC).METHODS: In a cohort of 565 consecutive hepatitis B-related HCC patients who underwent major liver resection, the characteristics and clinical outcomes after liver resection were compared between patients with immediate postoperative platelet count < 100 × 109/L and patients with platelet count ≥ 100 × 109/L. Risk factors for postoperative hepatic insufficiency were evaluated by multivariate analysis.RESULTS: Patients with a low immediate postoperative platelet count(< 100 × 109/L) had more grade Ⅲ-Ⅴ complications(20.5% vs 12.4%, P = 0.016), and higher rates of postoperative liver failure(6.8% vs 2.6%,P = 0.02), hepatic insufficiency(31.5% vs 21.2%, P < 0.001) and mortality(6.8% vs 0.5%, P < 0.001), compared to patients with a platelet count ≥ 100 × 109/L. The alanine aminotransferase levels on postoperative days 3 and 5, and bilirubin on postoperative days 1, 3 and 5 were higher in patients with immediate postoperative low platelet count. Multivariate analysis revealed that immediate postoperative low platelet count, rather than preoperative low platelet count, was a significant independent risk factor for hepatic insufficiency.CONCLUSION: A low immediate postoperative platelet count is an independent risk factor for hepatic insufficiency. Platelets can mediate liver regeneration in the cirrhotic liver. |
| doi_str_mv | 10.3748/wjg.v20.i33.11871 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4155380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>90888889504849525151485249</cqvip_id><sourcerecordid>1561469952</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-a8c57b8aeddb59bc69454ed8c739a2a2cdb42bb676ce89e8670710a8418688ab3</originalsourceid><addsrcrecordid>eNpVkUuP2yAURlHVqpPO9Ad0U7HsxilPA5tK1agvKdJsZtYI4-uEkW08BifKvy9p0qhlg-Ce-3HRQegDJWuuhP58eN6u94ysA-drSrWir9CKMWoqpgV5jVaUEFUZztQNepfSMyGMc8neohsmGamZESsEm3jAYRigDS4DnmLKcYLZ5bAvp77c9ZCxj8uYcUjYpRT9iWzxIeQd3sFUUI_DmJauCz7A6I_YdRnmcw18jsPxDr3pXJ_g_WW_RU_fvz3e_6w2Dz9-3X_dVF4IniunvVSNdtC2jTSNr42QAlrtFTeOOebbRrCmqVXtQRvQtSKKEqcF1bXWruG36Ms5d1qa8iUPY55db6c5DG4-2uiC_b8yhp3dxr0VVEquSQn4dAmY48sCKdshJA9970aIS7JU1lTUxkhWUHpG_RxTmqG7PkOJPemxRY8temzRY__oKT0f_53v2vHXRwH4JXQXx-1LGLdXxhB9WkYSoUUZQFJJhZZMGP4bbzOf7g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1561469952</pqid></control><display><type>article</type><title>Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy</title><source>MEDLINE</source><source>Baishideng "World Journal of" online journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Wang, Hai-Qing ; Yang, Jian ; Yang, Jia-Yin ; Wang, Wen-Tao ; Yan, Lu-Nan</creator><creatorcontrib>Wang, Hai-Qing ; Yang, Jian ; Yang, Jia-Yin ; Wang, Wen-Tao ; Yan, Lu-Nan</creatorcontrib><description>AIM: To investigate the relationship between low immediate postoperative platelet count and perioperative outcome after liver resection in patients with hepatocellular carcinoma(HCC).METHODS: In a cohort of 565 consecutive hepatitis B-related HCC patients who underwent major liver resection, the characteristics and clinical outcomes after liver resection were compared between patients with immediate postoperative platelet count &lt; 100 × 109/L and patients with platelet count ≥ 100 × 109/L. Risk factors for postoperative hepatic insufficiency were evaluated by multivariate analysis.RESULTS: Patients with a low immediate postoperative platelet count(&lt; 100 × 109/L) had more grade Ⅲ-Ⅴ complications(20.5% vs 12.4%, P = 0.016), and higher rates of postoperative liver failure(6.8% vs 2.6%,P = 0.02), hepatic insufficiency(31.5% vs 21.2%, P &lt; 0.001) and mortality(6.8% vs 0.5%, P &lt; 0.001), compared to patients with a platelet count ≥ 100 × 109/L. The alanine aminotransferase levels on postoperative days 3 and 5, and bilirubin on postoperative days 1, 3 and 5 were higher in patients with immediate postoperative low platelet count. Multivariate analysis revealed that immediate postoperative low platelet count, rather than preoperative low platelet count, was a significant independent risk factor for hepatic insufficiency.CONCLUSION: A low immediate postoperative platelet count is an independent risk factor for hepatic insufficiency. Platelets can mediate liver regeneration in the cirrhotic liver.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v20.i33.11871</identifier><identifier>PMID: 25206294</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Aged ; Alanine Transaminase - blood ; Bilirubin - blood ; Biomarkers - blood ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - surgery ; Chi-Square Distribution ; Female ; Hepatectomy - adverse effects ; Hepatectomy - mortality ; Hepatic ; Hepatic Insufficiency - blood ; Hepatic Insufficiency - diagnosis ; Hepatic Insufficiency - etiology ; Hepatic Insufficiency - mortality ; Hepatocellu ; Humans ; insufficiency ; Liver Failure - blood ; Liver Failure - etiology ; Liver Neoplasms - mortality ; Liver Neoplasms - surgery ; Liver Regeneration ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Observational Study ; Odds Ratio ; Platelet Count ; Predictive Value of Tests ; Risk Factors ; Thrombocytopenia ; Thrombocytopenia - blood ; Thrombocytopenia - diagnosis ; Thrombocytopenia - etiology ; Thrombocytopenia - mortality ; Time Factors ; Treatment Outcome</subject><ispartof>World journal of gastroenterology : WJG, 2014-09, Vol.20 (33), p.11871-11877</ispartof><rights>2014 Baishideng Publishing Group Inc. All rights reserved. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-a8c57b8aeddb59bc69454ed8c739a2a2cdb42bb676ce89e8670710a8418688ab3</citedby><cites>FETCH-LOGICAL-c443t-a8c57b8aeddb59bc69454ed8c739a2a2cdb42bb676ce89e8670710a8418688ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155380/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155380/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25206294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hai-Qing</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Yang, Jia-Yin</creatorcontrib><creatorcontrib>Wang, Wen-Tao</creatorcontrib><creatorcontrib>Yan, Lu-Nan</creatorcontrib><title>Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To investigate the relationship between low immediate postoperative platelet count and perioperative outcome after liver resection in patients with hepatocellular carcinoma(HCC).METHODS: In a cohort of 565 consecutive hepatitis B-related HCC patients who underwent major liver resection, the characteristics and clinical outcomes after liver resection were compared between patients with immediate postoperative platelet count &lt; 100 × 109/L and patients with platelet count ≥ 100 × 109/L. Risk factors for postoperative hepatic insufficiency were evaluated by multivariate analysis.RESULTS: Patients with a low immediate postoperative platelet count(&lt; 100 × 109/L) had more grade Ⅲ-Ⅴ complications(20.5% vs 12.4%, P = 0.016), and higher rates of postoperative liver failure(6.8% vs 2.6%,P = 0.02), hepatic insufficiency(31.5% vs 21.2%, P &lt; 0.001) and mortality(6.8% vs 0.5%, P &lt; 0.001), compared to patients with a platelet count ≥ 100 × 109/L. The alanine aminotransferase levels on postoperative days 3 and 5, and bilirubin on postoperative days 1, 3 and 5 were higher in patients with immediate postoperative low platelet count. Multivariate analysis revealed that immediate postoperative low platelet count, rather than preoperative low platelet count, was a significant independent risk factor for hepatic insufficiency.CONCLUSION: A low immediate postoperative platelet count is an independent risk factor for hepatic insufficiency. Platelets can mediate liver regeneration in the cirrhotic liver.</description><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Bilirubin - blood</subject><subject>Biomarkers - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Hepatectomy - adverse effects</subject><subject>Hepatectomy - mortality</subject><subject>Hepatic</subject><subject>Hepatic Insufficiency - blood</subject><subject>Hepatic Insufficiency - diagnosis</subject><subject>Hepatic Insufficiency - etiology</subject><subject>Hepatic Insufficiency - mortality</subject><subject>Hepatocellu</subject><subject>Humans</subject><subject>insufficiency</subject><subject>Liver Failure - blood</subject><subject>Liver Failure - etiology</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Regeneration</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Observational Study</subject><subject>Odds Ratio</subject><subject>Platelet Count</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombocytopenia - diagnosis</subject><subject>Thrombocytopenia - etiology</subject><subject>Thrombocytopenia - mortality</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUuP2yAURlHVqpPO9Ad0U7HsxilPA5tK1agvKdJsZtYI4-uEkW08BifKvy9p0qhlg-Ce-3HRQegDJWuuhP58eN6u94ysA-drSrWir9CKMWoqpgV5jVaUEFUZztQNepfSMyGMc8neohsmGamZESsEm3jAYRigDS4DnmLKcYLZ5bAvp77c9ZCxj8uYcUjYpRT9iWzxIeQd3sFUUI_DmJauCz7A6I_YdRnmcw18jsPxDr3pXJ_g_WW_RU_fvz3e_6w2Dz9-3X_dVF4IniunvVSNdtC2jTSNr42QAlrtFTeOOebbRrCmqVXtQRvQtSKKEqcF1bXWruG36Ms5d1qa8iUPY55db6c5DG4-2uiC_b8yhp3dxr0VVEquSQn4dAmY48sCKdshJA9970aIS7JU1lTUxkhWUHpG_RxTmqG7PkOJPemxRY8temzRY__oKT0f_53v2vHXRwH4JXQXx-1LGLdXxhB9WkYSoUUZQFJJhZZMGP4bbzOf7g</recordid><startdate>20140907</startdate><enddate>20140907</enddate><creator>Wang, Hai-Qing</creator><creator>Yang, Jian</creator><creator>Yang, Jia-Yin</creator><creator>Wang, Wen-Tao</creator><creator>Yan, Lu-Nan</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140907</creationdate><title>Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy</title><author>Wang, Hai-Qing ; Yang, Jian ; Yang, Jia-Yin ; Wang, Wen-Tao ; Yan, Lu-Nan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-a8c57b8aeddb59bc69454ed8c739a2a2cdb42bb676ce89e8670710a8418688ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Bilirubin - blood</topic><topic>Biomarkers - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Hepatectomy - adverse effects</topic><topic>Hepatectomy - mortality</topic><topic>Hepatic</topic><topic>Hepatic Insufficiency - blood</topic><topic>Hepatic Insufficiency - diagnosis</topic><topic>Hepatic Insufficiency - etiology</topic><topic>Hepatic Insufficiency - mortality</topic><topic>Hepatocellu</topic><topic>Humans</topic><topic>insufficiency</topic><topic>Liver Failure - blood</topic><topic>Liver Failure - etiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Regeneration</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Observational Study</topic><topic>Odds Ratio</topic><topic>Platelet Count</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombocytopenia - diagnosis</topic><topic>Thrombocytopenia - etiology</topic><topic>Thrombocytopenia - mortality</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Hai-Qing</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Yang, Jia-Yin</creatorcontrib><creatorcontrib>Wang, Wen-Tao</creatorcontrib><creatorcontrib>Yan, Lu-Nan</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hai-Qing</au><au>Yang, Jian</au><au>Yang, Jia-Yin</au><au>Wang, Wen-Tao</au><au>Yan, Lu-Nan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-09-07</date><risdate>2014</risdate><volume>20</volume><issue>33</issue><spage>11871</spage><epage>11877</epage><pages>11871-11877</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM: To investigate the relationship between low immediate postoperative platelet count and perioperative outcome after liver resection in patients with hepatocellular carcinoma(HCC).METHODS: In a cohort of 565 consecutive hepatitis B-related HCC patients who underwent major liver resection, the characteristics and clinical outcomes after liver resection were compared between patients with immediate postoperative platelet count &lt; 100 × 109/L and patients with platelet count ≥ 100 × 109/L. Risk factors for postoperative hepatic insufficiency were evaluated by multivariate analysis.RESULTS: Patients with a low immediate postoperative platelet count(&lt; 100 × 109/L) had more grade Ⅲ-Ⅴ complications(20.5% vs 12.4%, P = 0.016), and higher rates of postoperative liver failure(6.8% vs 2.6%,P = 0.02), hepatic insufficiency(31.5% vs 21.2%, P &lt; 0.001) and mortality(6.8% vs 0.5%, P &lt; 0.001), compared to patients with a platelet count ≥ 100 × 109/L. The alanine aminotransferase levels on postoperative days 3 and 5, and bilirubin on postoperative days 1, 3 and 5 were higher in patients with immediate postoperative low platelet count. Multivariate analysis revealed that immediate postoperative low platelet count, rather than preoperative low platelet count, was a significant independent risk factor for hepatic insufficiency.CONCLUSION: A low immediate postoperative platelet count is an independent risk factor for hepatic insufficiency. Platelets can mediate liver regeneration in the cirrhotic liver.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25206294</pmid><doi>10.3748/wjg.v20.i33.11871</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2014-09, Vol.20 (33), p.11871-11877 |
| issn | 1007-9327 2219-2840 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4155380 |
| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Alanine Transaminase - blood Bilirubin - blood Biomarkers - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - surgery Chi-Square Distribution Female Hepatectomy - adverse effects Hepatectomy - mortality Hepatic Hepatic Insufficiency - blood Hepatic Insufficiency - diagnosis Hepatic Insufficiency - etiology Hepatic Insufficiency - mortality Hepatocellu Humans insufficiency Liver Failure - blood Liver Failure - etiology Liver Neoplasms - mortality Liver Neoplasms - surgery Liver Regeneration Logistic Models Male Middle Aged Multivariate Analysis Observational Study Odds Ratio Platelet Count Predictive Value of Tests Risk Factors Thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - diagnosis Thrombocytopenia - etiology Thrombocytopenia - mortality Time Factors Treatment Outcome |
| title | Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T04%3A55%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20immediate%20postoperative%20platelet%20count%20is%20associated%20with%20hepatic%20insufficiency%20after%20hepatectomy&rft.jtitle=World%20journal%20of%20gastroenterology%20:%20WJG&rft.au=Wang,%20Hai-Qing&rft.date=2014-09-07&rft.volume=20&rft.issue=33&rft.spage=11871&rft.epage=11877&rft.pages=11871-11877&rft.issn=1007-9327&rft.eissn=2219-2840&rft_id=info:doi/10.3748/wjg.v20.i33.11871&rft_dat=%3Cproquest_pubme%3E1561469952%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1561469952&rft_id=info:pmid/25206294&rft_cqvip_id=90888889504849525151485249&rfr_iscdi=true |