FGF21 is an endocrine signal of protein restriction

Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 expression is induced by dietary protein restriction, but not energy restriction. Circulating FGF21 was increased 10-fold in mic...

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Veröffentlicht in:	The Journal of clinical investigation 2014-09, Vol.124 (9), p.3913-3922
Hauptverfasser:	Laeger, Thomas, Henagan, Tara M, Albarado, Diana C, Redman, Leanne M, Bray, George A, Noland, Robert C, Münzberg, Heike, Hutson, Susan M, Gettys, Thomas W, Schwartz, Michael W, Morrison, Christopher D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Biomedical research Caloric Restriction Data analysis Diet Diet, Ketogenic Dietary Proteins - administration & dosage Energy Metabolism Fibroblast growth factors Fibroblast Growth Factors - blood Fibroblast Growth Factors - genetics Fibroblast Growth Factors - physiology Gene expression Health aspects Hypotheses Liver Low-protein diet Male Mice Mice, Inbred C57BL Physiological aspects PPAR alpha - physiology Protein metabolism Protein research Protein-Serine-Threonine Kinases - physiology Proteins Rats Rats, Sprague-Dawley Rodents Scholarships & fellowships
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