Recombinant adenovirus-mediated overexpression of 3β-hydroxysteroid-Δ24 reductase

3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. The present study aimed to...

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Veröffentlicht in:	Neural regeneration research 2014-03, Vol.9 (5), p.504-512
Hauptverfasser:	Lu, Xiuli, Jia, Dan, Zhao, Chenguang, Wang, Weiqi, Liu, Ting, Chen, Shuchao, Quan, Xiaoping, Sun, Deliang, Gao, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Apoptosis Cholesterol Cloning Disease Gene therapy Genomes Nervous system Oxidative stress Plasmids Reactive oxygen species Technical Updates Vectors (Biology)
Online-Zugang:	Volltext
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