The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor

The minimum pharmacophore for activation of the human α7 nicotinic acetylcholine receptor (nAChR) is the tetramethylammonium cation. Previous work demonstrated that larger quaternary ammonium compounds, such as diethyldimethylammonium or 1-methyl quinuclidine, were α7-selective partial agonists, but...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-09, Vol.350 (3), p.665-680
Hauptverfasser:	Papke, Roger L, Chojnacka, Kinga, Horenstein, Nicole A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Allosteric Regulation - physiology alpha7 Nicotinic Acetylcholine Receptor - agonists alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Binding Sites - physiology Female Humans Neuropharmacology Nicotinic Agonists - metabolism Nicotinic Agonists - pharmacology Quaternary Ammonium Compounds - metabolism Quaternary Ammonium Compounds - pharmacology Xenopus laevis
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