Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study
The Renal and Lung Living Donors Evaluation Study assesses outcomes of live lung (lobectomy) donors. This is a retrospective cohort study at University of Southern California (USC) and Washington University (WASHU) Medical Centers (1993–2006), using medical records to assess morbidity and national d...
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| Veröffentlicht in: | American journal of transplantation 2014-08, Vol.14 (8), p.1846-1852 |
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| container_title | American journal of transplantation |
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| creator | Yusen, R. D. Hong, B. A. Messersmith, E. E. Gillespie, B. W. Lopez, B. M. Brown, K. L. Odim, J. Merion, R. M. Barr, M. L. |
| description | The Renal and Lung Living Donors Evaluation Study assesses outcomes of live lung (lobectomy) donors. This is a retrospective cohort study at University of Southern California (USC) and Washington University (WASHU) Medical Centers (1993–2006), using medical records to assess morbidity and national databases to ascertain postdonation survival and lung transplantation. Serious complications were defined as those that required significant treatment, were potentially life‐threatening or led to prolonged hospitalization. The 369 live lung donors (287 USC, 82 WASHU) were predominantly white, non‐Hispanic and male; 72% had a biological relationship to the recipient, and 30% were recipient parents. Serious complications occurred in 18% of donors; 2.2% underwent reoperation and 6.5% had an early rehospitalization. The two centers had significantly different incidences of serious complications (p |
| doi_str_mv | 10.1111/ajt.12771 |
| format | Article |
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This retrospective study of 369 live lung donors shows an 18% short‐term incidence of serious complications and no short‐ or long‐term mortality, and suggests a need for long‐term evaluation of morbidities and other important outcomes.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.12771</identifier><identifier>PMID: 25039865</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cohort Studies ; Databases, Factual ; Epidemiology ; Female ; General aspects ; Humans ; Length of Stay ; Live donors ; Living Donors - statistics & numerical data ; Lung - surgery ; Lung Diseases - mortality ; Lung Diseases - surgery ; Lung Transplantation ; Male ; Medical sciences ; Middle Aged ; Morbidity ; mortality ; outcomes ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality Control ; Research Design ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Transplants & implants ; Treatment Outcome ; Young Adult</subject><ispartof>American journal of transplantation, 2014-08, Vol.14 (8), p.1846-1852</ispartof><rights>Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6051-d058ae82bd3661e30c40883c96154f97f5b463a228388ce26b65a78abeab8ae63</citedby><cites>FETCH-LOGICAL-c6051-d058ae82bd3661e30c40883c96154f97f5b463a228388ce26b65a78abeab8ae63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.12771$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.12771$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28691580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25039865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yusen, R. D.</creatorcontrib><creatorcontrib>Hong, B. A.</creatorcontrib><creatorcontrib>Messersmith, E. E.</creatorcontrib><creatorcontrib>Gillespie, B. W.</creatorcontrib><creatorcontrib>Lopez, B. M.</creatorcontrib><creatorcontrib>Brown, K. L.</creatorcontrib><creatorcontrib>Odim, J.</creatorcontrib><creatorcontrib>Merion, R. M.</creatorcontrib><creatorcontrib>Barr, M. L.</creatorcontrib><creatorcontrib>RELIVE Study Group</creatorcontrib><title>Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>The Renal and Lung Living Donors Evaluation Study assesses outcomes of live lung (lobectomy) donors. This is a retrospective cohort study at University of Southern California (USC) and Washington University (WASHU) Medical Centers (1993–2006), using medical records to assess morbidity and national databases to ascertain postdonation survival and lung transplantation. Serious complications were defined as those that required significant treatment, were potentially life‐threatening or led to prolonged hospitalization. The 369 live lung donors (287 USC, 82 WASHU) were predominantly white, non‐Hispanic and male; 72% had a biological relationship to the recipient, and 30% were recipient parents. Serious complications occurred in 18% of donors; 2.2% underwent reoperation and 6.5% had an early rehospitalization. The two centers had significantly different incidences of serious complications (p < 0.001). No deaths occurred and no donors underwent lung transplantation during 4000+ person‐years of follow‐up (death: minimum 4, maximum 17 years; transplant: minimum 5, maximum 19). Live lung donation remains a potential option for recipients when using deceased donor lungs lacks feasibility. However, the use of two live donors for each recipient and the risk of morbidity associated with live lung donation do not justify this approach when deceased lung donors remain available. Center effects and long‐term live donor outcomes require further evaluation.
This retrospective study of 369 live lung donors shows an 18% short‐term incidence of serious complications and no short‐ or long‐term mortality, and suggests a need for long‐term evaluation of morbidities and other important outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Live donors</subject><subject>Living Donors - statistics & numerical data</subject><subject>Lung - surgery</subject><subject>Lung Diseases - mortality</subject><subject>Lung Diseases - surgery</subject><subject>Lung Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>mortality</subject><subject>outcomes</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Quality Control</subject><subject>Research Design</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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E.</creator><creator>Gillespie, B. W.</creator><creator>Lopez, B. M.</creator><creator>Brown, K. L.</creator><creator>Odim, J.</creator><creator>Merion, R. M.</creator><creator>Barr, M. L.</creator><general>Wiley</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201408</creationdate><title>Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study</title><author>Yusen, R. D. ; Hong, B. A. ; Messersmith, E. E. ; Gillespie, B. W. ; Lopez, B. M. ; Brown, K. L. ; Odim, J. ; Merion, R. M. ; Barr, M. 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Hygiene-occupational medicine</topic><topic>Quality Control</topic><topic>Research Design</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yusen, R. D.</creatorcontrib><creatorcontrib>Hong, B. A.</creatorcontrib><creatorcontrib>Messersmith, E. E.</creatorcontrib><creatorcontrib>Gillespie, B. W.</creatorcontrib><creatorcontrib>Lopez, B. M.</creatorcontrib><creatorcontrib>Brown, K. L.</creatorcontrib><creatorcontrib>Odim, J.</creatorcontrib><creatorcontrib>Merion, R. M.</creatorcontrib><creatorcontrib>Barr, M. L.</creatorcontrib><creatorcontrib>RELIVE Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yusen, R. D.</au><au>Hong, B. A.</au><au>Messersmith, E. E.</au><au>Gillespie, B. W.</au><au>Lopez, B. M.</au><au>Brown, K. L.</au><au>Odim, J.</au><au>Merion, R. M.</au><au>Barr, M. L.</au><aucorp>RELIVE Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2014-08</date><risdate>2014</risdate><volume>14</volume><issue>8</issue><spage>1846</spage><epage>1852</epage><pages>1846-1852</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>The Renal and Lung Living Donors Evaluation Study assesses outcomes of live lung (lobectomy) donors. This is a retrospective cohort study at University of Southern California (USC) and Washington University (WASHU) Medical Centers (1993–2006), using medical records to assess morbidity and national databases to ascertain postdonation survival and lung transplantation. Serious complications were defined as those that required significant treatment, were potentially life‐threatening or led to prolonged hospitalization. The 369 live lung donors (287 USC, 82 WASHU) were predominantly white, non‐Hispanic and male; 72% had a biological relationship to the recipient, and 30% were recipient parents. Serious complications occurred in 18% of donors; 2.2% underwent reoperation and 6.5% had an early rehospitalization. The two centers had significantly different incidences of serious complications (p < 0.001). No deaths occurred and no donors underwent lung transplantation during 4000+ person‐years of follow‐up (death: minimum 4, maximum 17 years; transplant: minimum 5, maximum 19). Live lung donation remains a potential option for recipients when using deceased donor lungs lacks feasibility. However, the use of two live donors for each recipient and the risk of morbidity associated with live lung donation do not justify this approach when deceased lung donors remain available. Center effects and long‐term live donor outcomes require further evaluation.
This retrospective study of 369 live lung donors shows an 18% short‐term incidence of serious complications and no short‐ or long‐term mortality, and suggests a need for long‐term evaluation of morbidities and other important outcomes.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>25039865</pmid><doi>10.1111/ajt.12771</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Cohort Studies Databases, Factual Epidemiology Female General aspects Humans Length of Stay Live donors Living Donors - statistics & numerical data Lung - surgery Lung Diseases - mortality Lung Diseases - surgery Lung Transplantation Male Medical sciences Middle Aged Morbidity mortality outcomes Public health. Hygiene Public health. Hygiene-occupational medicine Quality Control Research Design Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplants & implants Treatment Outcome Young Adult |
| title | Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study |
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