Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration

Ketamine is commonly used in pediatric anesthesia but may cause neurodegeneration in young brains. The aim of the study is to use an animal model to characterize the role of microRNA 137 (miR-137) in ketamine-induced neurodegeneration in neonatal hippocampus. Young Sprague-Dawley Rats (1 month old)...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2014-01, Vol.7 (8), p.5000-5007
Hauptverfasser:	Huang, Changshun, Zhang, Xingcai, Zheng, Jungang, Chen, Chunru, Chen, Yijun, Yi, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Dissociative - toxicity Animals cdc42 GTP-Binding Protein - biosynthesis Gene Expression Regulation Hippocampus - drug effects In Situ Nick-End Labeling Ketamine - toxicity Maze Learning - drug effects MicroRNAs - metabolism Nerve Degeneration - chemically induced Nerve Degeneration - prevention & control Original Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Up-Regulation
Online-Zugang:	Volltext
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