Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

A study investigating the mechanisms underlying lateral inhibition and lineage plasticity in the mouse small intestine crypts in vivo finds that crypt cells maintain a permissive chromatin state upon which a transcription factor acts to determine lineage specification, and this is the basis of later...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2014-02, Vol.506 (7489), p.511-515
Hauptverfasser:	Kim, Tae-Hee, Li, Fugen, Ferreiro-Neira, Isabel, Ho, Li-Lun, Luyten, Annouck, Nalapareddy, Kodandaramireddy, Long, Henry, Verzi, Michael, Shivdasani, Ramesh A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/51 38 45 45/15 631/136/142 631/532/2437 64 64/60 Animals Basic Helix-Loop-Helix Transcription Factors - deficiency Basic Helix-Loop-Helix Transcription Factors - metabolism Cell differentiation Cell Differentiation - genetics Cell Lineage - genetics Cell research Chromatin Chromatin - genetics Chromatin - metabolism Deoxyribonuclease I - metabolism DNA methylation Enhancer Elements, Genetic - genetics Enterocytes - cytology Enterocytes - metabolism Female Gene Expression Regulation Genetic transcription Genomics Histones - metabolism Humanities and Social Sciences Hypersensitivity Inhibition Intestine, Small - cytology Intestine, Small - metabolism letter Ligands Male Mice Mice, Inbred C57BL multidisciplinary Physiological aspects Plasticity Receptors, Notch - metabolism Rodents Science Stem cells Stem Cells - cytology Stem Cells - metabolism Transcription factors Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!