Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

Background. Ischemia/reperfusion (I/R) injury is a major cause of acute renal failure and allograft dysfunction in kidney transplantation. ROS/inflammatory cytokines are involved in I/R injury. 2-Methoxyestradiol (2ME2), an endogenous metabolite of estradiol, inhibits inflammatory cytokine expressio...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-11
Hauptverfasser:	Chen, Ying-Yin, Yeh, Ching-Hua, So, Edmund Cheung, Sun, Ding-Ping, Wang, Li-Yun, Hsing, Chung-Hsi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - genetics Acute Kidney Injury - pathology Adenovirus Animals Antimitotic agents Antineoplastic agents Apoptosis Biomedical research Brain research Cytochrome Cytokines Cytokines - biosynthesis Dosage and administration Estradiol Estradiol - administration & dosage Estradiol - analogs & derivatives Gangrene Gene expression Gene Expression Regulation Genetic aspects Health aspects Humans Hypoxia Inflammation - genetics Inflammation - pathology Ischemia Kidney diseases Kidney Transplantation - adverse effects Kidneys Laboratory animals Lipid peroxidation Mice Prevention Proteins Reperfusion injury Reperfusion Injury - drug therapy Reperfusion Injury - genetics Reperfusion Injury - pathology RNA, Messenger - biosynthesis Rodents Studies Survival analysis
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